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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mogtm1(cre)Gkl
targeted mutation 1, George Kollias
MGI:3689957
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl
Mogtm1(cre)Gkl/?
Tg(TcraCl4,TcrbCl4)1Shrm/0
involves: 129/Sv * BALB/c * C57BL/6 MGI:3805339
cn2
Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl
Mogtm1(cre)Gkl/?
involves: 129/Sv * C57BL/6 MGI:3805338
cn3
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 MGI:3690542
cn4
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
involves: C57BL/6 MGI:3690541
cn5
Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Mogtm1(cre)Gkl/?
involves: C57BL/6 MGI:3772815
cn6
Faddtm1Mpa/Faddtm1Mpa
Mogtm1(cre)Gkl/Mog+
involves: C57BL/6 * SJL MGI:4880724
cx7
Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch MGI:4461061


Genotype
MGI:3805339
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl
Mogtm1(cre)Gkl/?
Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic
Background
involves: 129/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HA)Libl mutation (0 available); any Gt(ROSA)26Sor mutation (784 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
Tg(TcraCl4,TcrbCl4)1Shrm mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 4 weeks after receiving transfer of HA-specific effector CD8 T cells, mice exhibit weight loss

behavior/neurological
• 4 weeks after receiving transfer of HA-specific effector CD8 T cells, severely affected animals display difficulty to right themselves when overturned
• 4 weeks after receiving transfer of HA-specific effector CD8 T cells (Tc1 cells), severely affected animals exhibit tremors
• 4 weeks after receiving transfer of HA-specific effector CD8 T cells, severely affected animals show reduced mobility

nervous system
• inflammation is also observed frequently in cerebellum, fornix and periventricular areas
• by 5 days following transfer of Tc1 cells, all mutants examined show spinal cord inflammation
• T cell infiltration into spinal cord starts on day 5 after transfer and peaks at day 28
• by 5 days following transfer of Tc1 cells, all mutants examined show optic nerve inflammation
• apoptosis in optic nerve and spinal cord is seen at early time points following Tc1 transfer
• focal areas with reduced myelin density and thin myelin sheaths are observed in animals after transfer of Tc1 cells
• vacuolization is seen at day 5 after Tc1 cell transfer
• by 5 days following transfer of Tc1 cells, demyelination is observed in the spinal cord and optic nerve
• from 9 days post-transfer, most mutants exhibit extensive demyelination in optic nerves
• by day 19, actively demyelinating lesions show severe axonal damage

vision/eye
• focal areas with reduced myelin density and thin myelin sheaths are observed in animals after transfer of Tc1 cells
• vacuolization is seen at day 5 after Tc1 cell transfer

immune system
• inflammation is also observed frequently in cerebellum, fornix and periventricular areas
• by 5 days following transfer of Tc1 cells, all mutants examined show spinal cord inflammation
• T cell infiltration into spinal cord starts on day 5 after transfer and peaks at day 28
• by 5 days following transfer of Tc1 cells, all mutants examined show optic nerve inflammation




Genotype
MGI:3805338
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl
Mogtm1(cre)Gkl/?
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HA)Libl mutation (0 available); any Gt(ROSA)26Sor mutation (784 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mutants do not show neurological signs when followed for up to 9 months of age

immune system
N
• no deletion of HA-specific CD8 T cells is observed




Genotype
MGI:3690542
cn3
Allelic
Composition
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Cgn mutation (1 available); any Fas mutation (76 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• B and T cell distribution in the lymph nodes is normal
• the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type
• mice are almost completely resistant to induction of experimental autoimmune encephalomyelitis (EAE) by injection of MOG p35-55
• almost no oligodendrocyte apoptosis after EAE induction unlike in wild-type mice
• reduction in demyelination and inflammation after induction of EAE is greater than in mutant mice wild-type for Tnfrsf1a
• 24 days after induction of EAE, minimal axonal injury is seen in spinal cords




Genotype
MGI:3690541
cn4
Allelic
Composition
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Cgn mutation (1 available); any Fas mutation (76 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type
• reduction in the onset and severity, but not incidence, of experimental autoimmune encephalomyelitis (EAE) induced by injection of MOG p35-55
• demyelination induced by injection of MOG p35-55 is reduced by about 70% compared to wild-type
• perivascular and parenchymal infiltration by T lymphocytes and macrophages is also reduced after induction of EAE
• mild reduction in oligodendrocyte apoptosis after EAE induction




Genotype
MGI:3772815
cn5
Allelic
Composition
Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Mogtm1(cre)Gkl/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HBEGF)Awai mutation (4 available); any Gt(ROSA)26Sor mutation (784 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with weight loss after ~30 days

behavior/neurological
• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with tremor after ~30 days
• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with hindlimb paralysis after ~30 days

nervous system
• 3 days following diptheria toxin injection 3 times daily for 7 days, substantial apoptosis is detected in the granular layer of the cerebella of double mutants; cells are likely oligodendrocytes, but may be granule cells
• reactive astrogliosis is observed, as well as inflammatory cells, in oligodendrocytes after diptheria toxin injection 3 times daily for 7 days
• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, severe destruction of myelinated structures throughout the CNS is observed
• diptheria toxin-induced demyelination is observed in treated double mutants

immune system
• after diptheria toxin treatment for 7 days, low titers of IgM diptheria toxin-specific antibodies are detected in the serum; DT-specific IgG1 antibodies are detected later, and amounts are ~50-fold lower than in a typical hapten-induced antiboby response

cellular
• 3 days following diptheria toxin injection 3 times daily for 7 days, substantial apoptosis is detected in the granular layer of the cerebella of double mutants; cells are likely oligodendrocytes, but may be granule cells




Genotype
MGI:4880724
cn6
Allelic
Composition
Faddtm1Mpa/Faddtm1Mpa
Mogtm1(cre)Gkl/Mog+
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Mpa mutation (0 available); any Fadd mutation (12 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• peripheral T cell activation is normal
• MOG35-55-treated mice exhibit less severe disease and reduced oligodendrocyte apoptosis compared with similarly treated wild-type mice
• however, MOG35-55-treated mice exhibit normal T cell activation

nervous system
N
• mice exhibit normal myelination
• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice

cellular
• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice




Genotype
MGI:4461061
cx7
Allelic
Composition
Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• between 15% and 20% of mice develop spontaneous EAE

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
J:151335





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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory