Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Nf1tm1Par mutation
(4 available);
any
Nf1 mutation
(157 available)
Tg(Fabp7-cre,-lacZ)3Gtm mutation
(1 available)
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nervous system
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• significantly smaller than control littermates
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growth/size/body
endocrine/exocrine glands
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• significantly smaller than control littermates
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homeostasis/metabolism
mortality/aging
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• 2 embryos are found at later stages, after expected midgestation lethality from cardiovascular failure
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hematopoietic system
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• mice display moderate splenic enlargement and partial rescue of splenic architecture
• germinal centers are present
• splenic fibrosis is not observed
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immune system
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• mice display moderate splenic enlargement and partial rescue of splenic architecture
• germinal centers are present
• splenic fibrosis is not observed
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nervous system
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• marked enlargement of dorsal root ganglia and other neural crest derived tissues is observed
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Hprt1tm1(CMV-cre)Brd mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Nf1tm1Fcr mutation
(3 available);
any
Nf1 mutation
(157 available)
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mortality/aging
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• some mice (5/208) survive to birth while all Nf1-null homozygotes expressing either Gt(ROSA)26Sortm1Fia or Hprt1tm1(CMV-cre)Brd die prior to birth
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nervous system
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• peripheral ganglia are massively enlarged in newborns
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• enormous paraspinal masses arise from the dorsal root ganglia
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endocrine/exocrine glands
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• medulla is overgrown compared with wild-type, with cortical effacement and tumor-like medullary protrusion
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Hprt1tm1(CMV-cre)Brd mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Nf1tm1Fcr mutation
(3 available);
any
Nf1 mutation
(157 available)
|
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nervous system
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• peripheral ganglia are massively enlarged in newborns
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