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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arid4btm1Alb
targeted mutation 1, Arthur L Beaudet
MGI:3687005
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arid4btm1Alb/Arid4btm1Alb involves: 129S7/SvEvBrd * C57BL/6 MGI:3717485
ht2
Arid4btm1Alb/Arid4b+ involves: 129S7/SvEvBrd * C57BL/6 MGI:3717486
cx3
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
involves: 129S7/SvEvBrd MGI:3817455
cx4
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4btm1Alb
involves: 129S7/SvEvBrd * C57BL/6 MGI:3717487
cx5
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
involves: 129S7/SvEvBrd * C57BL/6 MGI:3717488
cx6
Arid4btm1Alb/Arid4b+
Snrpntm4Alb/Snrpn+
involves: 129S7/SvEvBrd * C57BL/6 MGI:3717489


Genotype
MGI:3717485
hm1
Allelic
Composition
Arid4btm1Alb/Arid4btm1Alb
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4btm1Alb mutation (0 available); any Arid4b mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• few embryos are recovered at E3.5 and none at E7.5




Genotype
MGI:3717486
ht2
Allelic
Composition
Arid4btm1Alb/Arid4b+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4btm1Alb mutation (0 available); any Arid4b mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• DNA methylation is normal




Genotype
MGI:3817455
cx3
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (32 available)
Arid4btm1Alb mutation (0 available); any Arid4b mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 25% of mice die before 1 month
• mice exhibit increased mortality at 7 months of age

hematopoietic system
• increased in the spleen and bone marrow
• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• the peripheral blood of mice with acute myeloid leukemia (AML) contains more than 20% atypical cells with morphology consistent with blasts and immature myeloid precursors unlike in wild-type mice
• the bone marrow of mice with acute myeloid leukemia (AML)
• the spleen of mice of mice with acute myeloid leukemia (AML)
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• the bone marrow and spleens of mice with acute myeloid leukemia (AML)
• the spleen of mice with acute myeloid leukemia (AML)
• the bone marrow spleens of mice with acute myeloid leukemia (AML)
• in mice with acute myeloid leukemia (AML)
• the bone marrow of mice with acute myeloid leukemia (AML)
• mice with acute myeloid leukemia (AML) exhibit monocytosis and hemophagocytosis
• hematopoietic stem cell populations are expanded in the bone marrow and spleen compared to in wild-type mice and Arid4atm1Alb homozygotes
• in mice with acute myeloid leukemia (AML)

neoplasm
• 83% of mice develop acute myeloid leukemia between 7 and 15 months of age
• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

liver/biliary system
• in mice with acute myeloid leukemia (AML)

skeleton
• mice that exhibit acute myeloid leukemia (AML) also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• the bone marrow of mice with AML increase in granulocytes, monocytes, T lymphoid cells, and erythroid cells and a decrease in B lymphoid cells compared to in wild-type mice
• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice and Arid4atm1Alb homozygotes

respiratory system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

cardiovascular system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung, kidney and lymph node blood vessels indicative of leukemic involvement
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

renal/urinary system
• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement

growth/size/body
• at 7 weeks of age, mice weigh 30% less than wild-type mice

immune system
• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice
• in the peripheral blood of mice with acute myeloid leukemia (AML)
• the bone marrow and spleens of mice with acute myeloid leukemia (AML)
• the spleen of mice with acute myeloid leukemia (AML)
• the bone marrow spleens of mice with acute myeloid leukemia (AML)
• in mice with acute myeloid leukemia (AML)
• the bone marrow of mice with acute myeloid leukemia (AML)
• mice with acute myeloid leukemia (AML) exhibit monocytosis and hemophagocytosis
• in mice with acute myeloid leukemia (AML)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Acute Myeloid; AML 601626 J:141004




Genotype
MGI:3717487
cx4
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4btm1Alb
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (32 available)
Arid4btm1Alb mutation (0 available); any Arid4b mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3717488
cx5
Allelic
Composition
Arid4atm1Alb/Arid4atm1Alb
Arid4btm1Alb/Arid4b+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4atm1Alb mutation (0 available); any Arid4a mutation (32 available)
Arid4btm1Alb mutation (0 available); any Arid4b mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 1 of 7 mice lacks correct DNA methylation patterns
• trimethylation at H4K20 is lost in all mice
• maternal imprinting is defective

reproductive system




Genotype
MGI:3717489
cx6
Allelic
Composition
Arid4btm1Alb/Arid4b+
Snrpntm4Alb/Snrpn+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4btm1Alb mutation (0 available); any Arid4b mutation (37 available)
Snrpntm4Alb mutation (0 available); any Snrpn mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• 14 of 18 mice lack correct DNA methylation patterns





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory