All Phenotypes Ctcf<tm2Gal> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctcf^tm2Gal/Ctcf^tm2Gal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * C57BL/10	MGI:3829023
cn2	Ctcf^tm2Gal/Ctcf^tm2Gal Tg(Lck-cre)1Cwi/0 Tg(TcraTcrb)425Cbn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3829020
cn3	Ctcf^tm2Gal/Ctcf⁺ Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3829017
cn4	Ctcf^tm2Gal/Ctcf^tm2Gal Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3829016
cn5	Ctcf^tm2Gal/Ctcf^tm2Gal Tg(Lck-cre)1Cwi/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J	MGI:3829022

Allelic Composition	Ctcf^tm2Gal/Ctcf^tm2Gal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcf^tm2Gal mutation (0 available); any Ctcf mutation (78 available)
Rag2^tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:143271 )

• despite increased double positive T cell production stimulated by anti-CD3epsilon treatment, mice produce fewer double positive T cells compared to similarly treated Rag2^tm1Fwa homozygotes

hematopoietic system

decreased double-positive T cell number ( J:143271 )

• despite increased double positive T cell production stimulated by anti-CD3epsilon treatment, mice produce fewer double positive T cells compared to similarly treated Rag2^tm1Fwa homozygotes

Allelic Composition	Ctcf^tm2Gal/Ctcf^tm2Gal Tg(Lck-cre)1Cwi/0 Tg(TcraTcrb)425Cbn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcf^tm2Gal mutation (0 available); any Ctcf mutation (78 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

increased double-negative T cell number ( J:143271 )

decreased double-positive T cell number ( J:143271 )

decreased T cell number ( J:143271 )

• mice exhibit an almost complete lack of mature T cells in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

increased single-positive T cell number ( J:143271 )

• the number of immature single positive cells in the thymus is increased compared to in wild-type mice

hematopoietic system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

increased double-negative T cell number ( J:143271 )

decreased T cell number ( J:143271 )

• mice exhibit an almost complete lack of mature T cells in the spleen

decreased double-positive T cell number ( J:143271 )

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

increased single-positive T cell number ( J:143271 )

• the number of immature single positive cells in the thymus is increased compared to in wild-type mice

Allelic Composition	Ctcf^tm2Gal/Ctcf⁺ Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcf^tm2Gal mutation (0 available); any Ctcf mutation (78 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:143271 )

• modestly

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

hematopoietic system

thymus hypoplasia ( J:143271 )

• modestly

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

endocrine/exocrine glands

thymus hypoplasia ( J:143271 )

• modestly

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:143271 )

abnormal T cell morphology ( J:143271 )

• cells at the DN3L to immature single positive stage are smaller than in wild-type mice while double positive cells are larger than in wild-type mice

abnormal T cell differentiation ( J:143271 )

• alpha beta T cell differentiation is defective

• the number of DN3, DN4 and immature single positive cells is increased compared to in wild-type mice

• mice exhibit only a 4-fold increase in thymocytes during the transition from immature single positive to double positive T cells compared to a 90-fold increase in wild-type mice

• however, sigma delta T cell differentiation and TCR rearrangement are normal

• mice exhibit a defect in the transition from immature single positive cells to double positive cells

• the number of immature single positive T cells undergoing cell cycling is half as many as in wild-type mice

increased double-negative T cell number ( J:143271 )

• the number of double negative DN3 and DN4 cells is increased compared to in wild-type mice

decreased double-positive T cell number ( J:143271 )

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

decreased single-positive T cell number ( J:143271 )

• the number of mature single positive T cells is decreased compared to in wild-type mice

increased single-positive T cell number ( J:143271 )

• the number of immature single positive cells in the thymus is increased compared to in wild-type mice

hematopoietic system

thymus hypoplasia ( J:143271 )

abnormal T cell morphology ( J:143271 )

• cells at the DN3L to immature single positive stage are smaller than in wild-type mice while double positive cells are larger than in wild-type mice

abnormal T cell differentiation ( J:143271 )

• alpha beta T cell differentiation is defective

• the number of DN3, DN4 and immature single positive cells is increased compared to in wild-type mice

• mice exhibit only a 4-fold increase in thymocytes during the transition from immature single positive to double positive T cells compared to a 90-fold increase in wild-type mice

• however, sigma delta T cell differentiation and TCR rearrangement are normal

• mice exhibit a defect in the transition from immature single positive cells to double positive cells

• the number of immature single positive T cells undergoing cell cycling is half as many as in wild-type mice

increased double-negative T cell number ( J:143271 )

• the number of double negative DN3 and DN4 cells is increased compared to in wild-type mice

decreased double-positive T cell number ( J:143271 )

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice

• however, the ratio of mature single positive cells to double positive cells is normal

decreased single-positive T cell number ( J:143271 )

• the number of mature single positive T cells is decreased compared to in wild-type mice

increased single-positive T cell number ( J:143271 )

• the number of immature single positive cells in the thymus is increased compared to in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:143271 )

Allelic Composition	Ctcf^tm2Gal/Ctcf^tm2Gal Tg(Lck-cre)1Cwi/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

• mice exhibit a severe block to T cell development at the immature single positive stage

decreased double-positive T cell number ( J:143271 )

• mice exhibit a almost complete lack of double positive cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

hematopoietic system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

• mice exhibit a severe block to T cell development at the immature single positive stage

decreased double-positive T cell number ( J:143271 )

• mice exhibit a almost complete lack of double positive cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:143271 )

• strongly reduced in the spleen

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