Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation
(4 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
Xrcc4tm2.1Fwa mutation
(0 available);
any
Xrcc4 mutation
(25 available)
Xrcc4tm2Fwa mutation
(0 available);
any
Xrcc4 mutation
(25 available)
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mortality/aging
N |
• mice survive beyond 16 months
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation
(4 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
Xrcc4tm2.1Fwa mutation
(0 available);
any
Xrcc4 mutation
(25 available)
Xrcc4tm2Fwa mutation
(0 available);
any
Xrcc4 mutation
(25 available)
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mortality/aging
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• mice become moribund between 12 and 14 weeks of age with 20/23 mice dead by 25 weeks
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nervous system
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• mice develop medulloblastomas
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• mice at 4 and 8.5 weeks of age show multifocal tumor masses expanding from the granular layer
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• at 12-14 weeks mice have aggressive medulloblastomas in the vermis or hemisphere
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craniofacial
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• at 12-14 weeks skulls of mice show rapid morphological enlargement
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skeleton
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• at 12-14 weeks skulls of mice show rapid morphological enlargement
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neoplasm
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• mice develop medulloblastomas
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