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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tyrc-Brd
albino, Allan Bradley
MGI:3640303
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tyrc-Brd/Tyrc-Brd C57BL/6Brd-Tyrc-Brd MGI:3692731
cn2
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:5008633
cn3
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:5008634
cn4
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * C57BL/6 MGI:5008632
cx5
Dp(11Cops3-Rnf112)1Jrl/0
Tyrc-Brd/Tyrc-Brd
B6Brd.Cg-Tyrc-Brd Dp(11Cops3-Rnf112)1Jrl MGI:3758726
cx6
Lgi1tm1.1Jkc/Lgi1+
Tyrc-Brd/Tyrc-Brd
B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc MGI:4440616
cx7
Lgi1tm1.1Jkc/Lgi1tm1.1Jkc
Tyrc-Brd/Tyrc-Brd
B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc MGI:4440340
cx8
In(11Trp53;11Wnt3)8Brd/+
Tyrc-Brd/Tyrc-Brd
involves: 129S7/SvEvBrd * C57BL/6Brd MGI:5766501


Genotype
MGI:3692731
hm1
Allelic
Composition
Tyrc-Brd/Tyrc-Brd
Genetic
Background
C57BL/6Brd-Tyrc-Brd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the hair coat of homozygous mutant mice is entirely white
• the skin of homozygous mutant mice is pink in both furred and unfurred (e.g., tail, ear pinnae, feet) regions
• the eyes of homozygous mutant mice are pink

vision/eye
• the eyes of homozygous mutant mice are pink

integument
• the hair coat of homozygous mutant mice is entirely white
• the skin of homozygous mutant mice is pink in both furred and unfurred (e.g., tail, ear pinnae, feet) regions




Genotype
MGI:5008633
cn2
Allelic
Composition
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tyrc-Brd/Tyrc-Brd
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (534 available)
Ptentm1Hwu mutation (5 available); any Pten mutation (40 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

mortality/aging
• median survival is 85 days following injection of PDGF and cre compared with 27 days for similarly treated Ptentm1Hwu Trp53tm1Thl double homozygotes

neoplasm
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
glioblastoma proneural subtype DOID:0050804 J:172585




Genotype
MGI:5008634
cn3
Allelic
Composition
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (534 available)
Ptentm1Hwu mutation (5 available); any Pten mutation (40 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (156 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

mortality/aging
• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Ptentm1Hwu homozygotes

neoplasm
• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Ptentm1Hwu homozygotes
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
glioblastoma proneural subtype DOID:0050804 J:172585




Genotype
MGI:5008632
cn4
Allelic
Composition
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Tyrc-Brd/Tyrc-Brd
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (534 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• following injection of PDGF and cre, mice do not develop tumor-related morbidity

neoplasm
N
• following injection of PDGF and cre, mice do not develop tumor-related morbidity




Genotype
MGI:3758726
cx5
Allelic
Composition
Dp(11Cops3-Rnf112)1Jrl/0
Tyrc-Brd/Tyrc-Brd
Genetic
Background
B6Brd.Cg-Tyrc-Brd Dp(11Cops3-Rnf112)1Jrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(11Cops3-Rnf112)1Jrl mutation (1 available); any Dp(11Cops3-Rnf112)1Jrl mutation (1 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impaired contextual conditioning (12.6+/-2.5% freezing to context compared to 36.0+/-6.5 in wild-type mice)
• mice exhibit decreased center to total distance ratio explored (0.26+/-0.01 compared to 0.33+/-0.04 in wild-type mice)
• in an elevated plus maze
• mice exhibit decreased vertical activity (305+/-22 incidents compared to 499+/-60 incidences in wild-type mice)
• mice exhibit increased dominance compared with wild-type mice
• however, mice exhibit normal aggression
• 6.5 hours after introducing a paper towel to cages, only half of mice build nest compared with all wild-type mice
• mice exhibit impaired sociability and response to social novelty compared with wild-type mice
• only half of mice vocalize during handling compared with all wild-type mice

nervous system
• at 12 weeks

growth/size/body
• at 12 weeks

adipose tissue

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Potocki-Lupski syndrome DOID:0060853 OMIM:610883
J:138598




Genotype
MGI:4440616
cx6
Allelic
Composition
Lgi1tm1.1Jkc/Lgi1+
Tyrc-Brd/Tyrc-Brd
Genetic
Background
B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm1.1Jkc mutation (1 available); any Lgi1 mutation (7 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• due to the C57BL/6-Tyrc-Brd background
• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice

vision/eye
• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice

integument
• due to the C57BL/6-Tyrc-Brd background




Genotype
MGI:4440340
cx7
Allelic
Composition
Lgi1tm1.1Jkc/Lgi1tm1.1Jkc
Tyrc-Brd/Tyrc-Brd
Genetic
Background
B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm1.1Jkc mutation (1 available); any Lgi1 mutation (7 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 12 to 20 days of age, mice exhibit myoclonic seizures accompanied by rapid jumping and running and die shortly after

nervous system
N
• mice exhibit normal miniature inhibitory postsynaptic current frequency and amplitude and inhibitory postsynaptic currents
• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice
• however, firing frequency and spikes as well as resting membrane potential are normal
• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after
• AMPA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice
• NMDA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice
• mice exhibit increased frequency of miniature excitatory postsynaptic currents compared with wild-type mice

growth/size/body
• slight in some mice

behavior/neurological
• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice
• however, firing frequency and spikes as well as resting membrane potential are normal
• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after

pigmentation
• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyrc-Brd control mice
• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice

vision/eye
• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice

integument
• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyrc-Brd control mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial temporal lobe epilepsy 1 DOID:0060748 OMIM:600512
J:158715




Genotype
MGI:5766501
cx8
Allelic
Composition
In(11Trp53;11Wnt3)8Brd/+
Tyrc-Brd/Tyrc-Brd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6Brd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (2 available); any In(11Trp53;11Wnt3)8Brd mutation (5 available)
Tyrc-Brd mutation (7 available); any Tyr mutation (318 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• the inversion has no effect on coat color in an albino background, suggesting the tyrosinase minigene in the Trp53 gene is inactive in the inversion chromosome.





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory