Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-Brd mutation
(6 available);
any
Tyr mutation
(375 available)
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pigmentation
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• the hair coat of homozygous mutant mice is entirely white
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• the skin of homozygous mutant mice is pink in both furred and unfurred (e.g., tail, ear pinnae, feet) regions
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• the eyes of homozygous mutant mice are pink
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vision/eye
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• the eyes of homozygous mutant mice are pink
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integument
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• the hair coat of homozygous mutant mice is entirely white
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• the skin of homozygous mutant mice is pink in both furred and unfurred (e.g., tail, ear pinnae, feet) regions
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mortality/aging
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• median survival is 85 days following injection of PDGF and cre compared with 27 days for similarly treated Ptentm1Hwu Trp53tm1Thl double homozygotes
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neoplasm
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• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells
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nervous system
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• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells
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mortality/aging
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• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Ptentm1Hwu homozygotes
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neoplasm
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• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Ptentm1Hwu homozygotes
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• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells
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nervous system
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• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tyrc-Brd mutation
(6 available);
any
Tyr mutation
(375 available)
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mortality/aging
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N |
• following injection of PDGF and cre, mice do not develop tumor-related morbidity
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neoplasm
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N |
• following injection of PDGF and cre, mice do not develop tumor-related morbidity
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behavior/neurological
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• mice exhibit impaired contextual conditioning (12.6+/-2.5% freezing to context compared to 36.0+/-6.5 in wild-type mice)
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• mice exhibit decreased center to total distance ratio explored (0.26+/-0.01 compared to 0.33+/-0.04 in wild-type mice)
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• in an elevated plus maze
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• mice exhibit decreased vertical activity (305+/-22 incidents compared to 499+/-60 incidences in wild-type mice)
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• mice exhibit increased dominance compared with wild-type mice
• however, mice exhibit normal aggression
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• 6.5 hours after introducing a paper towel to cages, only half of mice build nest compared with all wild-type mice
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• mice exhibit impaired sociability and response to social novelty compared with wild-type mice
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• only half of mice vocalize during handling compared with all wild-type mice
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nervous system
growth/size/body
adipose tissue
pigmentation
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• due to the C57BL/6-Tyrc-Brd background
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• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice
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vision/eye
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• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice
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integument
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• due to the C57BL/6-Tyrc-Brd background
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mortality/aging
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• at 12 to 20 days of age, mice exhibit myoclonic seizures accompanied by rapid jumping and running and die shortly after
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nervous system
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N |
• mice exhibit normal miniature inhibitory postsynaptic current frequency and amplitude and inhibitory postsynaptic currents
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• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice
• however, firing frequency and spikes as well as resting membrane potential are normal
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• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after
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• AMPA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice
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• NMDA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice
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• mice exhibit increased frequency of miniature excitatory postsynaptic currents compared with wild-type mice
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growth/size/body
behavior/neurological
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• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice
• however, firing frequency and spikes as well as resting membrane potential are normal
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• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after
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pigmentation
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• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyrc-Brd control mice
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• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice
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vision/eye
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• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice
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integument
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• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyrc-Brd control mice
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pigmentation
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N |
• the inversion has no effect on coat color in an albino background, suggesting the tyrosinase minigene in the Trp53 gene is inactive in the inversion chromosome.
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Analysis Tools