Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4tm1Dgen mutation
(2 available);
any
Gria4 mutation
(72 available)
|
|
|
behavior/neurological
|
• higher doses of metrazol are needed to induce some seizure stages while lower doses are needed to induce other stages
|
|
• increase in the total the distance traveled in an open field
|
|
• prolonged latency in hot plate test
|
nervous system
|
• higher doses of metrazol are needed to induce some seizure stages while lower doses are needed to induce other stages
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4tm1Dgen mutation
(2 available);
any
Gria4 mutation
(72 available)
|
|
|
behavior/neurological
|
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)
|
nervous system
|
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)
|
Allelic Composition |
Gria4tm1Dgen/Gria4+
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4tm1Dgen mutation
(2 available);
any
Gria4 mutation
(72 available)
|
|
|
behavior/neurological
|
• the spike wave discharge incidence observed in the F1 C3H intercross is slightly lower than that observed in homozygous C3H/HeJ animals
|
nervous system
|
• the spike wave discharge incidence observed in the F1 C3H intercross is slightly lower than that observed in homozygous C3H/HeJ animals
|
behavior/neurological
|
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)
|
nervous system
|
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)
|