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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Camltm2Rjb
targeted mutation 2, Richard J Bram
MGI:3589391
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Camltm1Rjb/Camltm2Rjb
Tg(Lck-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 MGI:3590220
cn2
Camltm1Rjb/Camltm2Rjb
Tg(Lck-cre)1Cwi/0
Tg(TcraTcrb)1100Mjb/0
involves: 129 * C57BL/6 * DBA/2 MGI:3590221


Genotype
MGI:3590220
cn1
Allelic
Composition
Camltm1Rjb/Camltm2Rjb
Tg(Lck-cre)1Cwi/0
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camltm1Rjb mutation (0 available); any Caml mutation (3 available)
Camltm2Rjb mutation (0 available); any Caml mutation (3 available)
Tg(Lck-cre)1Cwi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation
• the average numbers of total thymocytes were reduced by half
• the number of cells at the double-negative stage was not different
• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control
• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells
• in 8-9 weeks old mutant mice, T cell numbers were more similar

immune system
• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation
• the average numbers of total thymocytes were reduced by half
• the number of cells at the double-negative stage was not different
• 4- to 6-fold fewer CD4 and CD8 single-positive cells compared to control
• in 3-4 weeks old mutant mice, there were 7- to 9-fold fewer peripheral CD4+ and CD8+ T cells
• in 8-9 weeks old mutant mice, T cell numbers were more similar

cellular
• double-positive thymocytes from mutant mice undergo enhanced apoptosis by TCR-stimulation

endocrine/exocrine glands
• the average numbers of total thymocytes were reduced by half
• the number of cells at the double-negative stage was not different




Genotype
MGI:3590221
cn2
Allelic
Composition
Camltm1Rjb/Camltm2Rjb
Tg(Lck-cre)1Cwi/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camltm1Rjb mutation (0 available); any Caml mutation (3 available)
Camltm2Rjb mutation (0 available); any Caml mutation (3 available)
Tg(Lck-cre)1Cwi mutation (2 available)
Tg(TcraTcrb)1100Mjb mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced numbers of total thymocytes
• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection
• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

immune system
• reduced numbers of total thymocytes
• in an in vitro assay, mutant thymocytes underwent OCA peptide 257-264 dependent cell death more readily than control, indicating enhanced negative selection
• lower proportions of double-positive and single-positive cells, and reduced CD8 SP cell in the peripheral T cell population, both indicating impaired positive selection

endocrine/exocrine glands
• reduced numbers of total thymocytes





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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory