Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation
(0 available);
any
Ccne1 mutation
(23 available)
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hematopoietic system
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• a 4-fold increase in the number of proliferating splenocytes is seen
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• spleen weight is 1-2 times that of wild-type
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• mild extramedullary hematopoiesis
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cellular
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• MEFs immortalize earlier than wild-type cells
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• a 4-fold increase in the number of proliferating splenocytes is seen
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immune system
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• a 4-fold increase in the number of proliferating splenocytes is seen
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• spleen weight is 1-2 times that of wild-type
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growth/size/body
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• spleen weight is 1-2 times that of wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation
(0 available);
any
Ccne1 mutation
(23 available)
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reproductive system
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N |
• despite in increase in mammary epithelia, mammary gland morphology during pregnancy and involution is normal
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digestive/alimentary system
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N |
• despite in increase in gut epithelia, adult colonic morphology is normal
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• gut epithelium exhibits increased proliferation and apoptosis compared to in wild-type mice
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endocrine/exocrine glands
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• mammary epithelium exhibits increased proliferation compared to in wild-type mice
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• mammary epithelium exhibits increased apoptosis compared to in wild-type mice
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integument
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• mammary epithelium exhibits increased proliferation compared to in wild-type mice
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• mammary epithelium exhibits increased apoptosis compared to in wild-type mice
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cellular
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• mammary epithelium exhibits increased proliferation compared to in wild-type mice
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Allelic
Composition |
Ccne1tm1Jro/?
Trp53tm1Tyj/Trp53tm1Tyj
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Genetic
Background |
either: (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J) or (involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation
(0 available);
any
Ccne1 mutation
(23 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
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cellular
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• cell proliferation in double mutant MEFs is increased compared to MEFs homozygous null for Trp53 alone
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neoplasm
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• mean tumor-free survival is reduced to 145 days compared to 180 days in mice homozygous null for Trp53 alone
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Allelic
Composition |
Ccne1tm1Jro/?
Cdkn1atm1Led/Cdkn1atm1Led
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Genetic
Background |
either: (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J) or (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6J) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation
(0 available);
any
Ccne1 mutation
(23 available)
Cdkn1atm1Led mutation
(1 available);
any
Cdkn1a mutation
(60 available)
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cellular
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• during a 3T3 immortalization protocol double mutant MEFs display grossly altered cell morphology unlike MEFs homozygous null for Cdkn1a alone
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• cell proliferation in double mutant MEFs is reduced compared to MEFs homozygous null for Cdkn1a alone
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• double mutant MEFs have more cells that are tetraploid in early passages and aneuploid in later passages compared to MEFs homozygous null for Cdkn1a alone
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Allelic
Composition |
Ccne1tm1Jro/?
Krastm3Tyj/?
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Genetic
Background |
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation
(0 available);
any
Ccne1 mutation
(23 available)
Krastm3Tyj mutation
(2 available);
any
Kras mutation
(76 available)
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mortality/aging
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• mean survival is reduced to 160 days compared to 260 days for mice homozygous for Kras alone
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cellular
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• 2 of 6 tumors from double mutants display significant gains or losses of whole chromosomes while no gains or losses of whole chromosomes are seen in Kras homozygotes
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Analysis Tools