Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6ka5tm1Jsca mutation
(0 available);
any
Rps6ka5 mutation
(63 available)
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behavior/neurological
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• although mice experience a hyperlocomotor phase following initial exposure to cocaine no continued increase in locomotor activities is seen with repeated administration of the drug
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• mice are conditioned at lower doses (10mg/kg) of cocaine and after conditioning spent significantly more time in the cocaine-associated side
• mice showed no increased response at 20mg/kg
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6ka5tm1Jsca mutation
(0 available);
any
Rps6ka5 mutation
(63 available)
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homeostasis/metabolism
nervous system
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• 3-NP, a mitochondrial neurotoxin, results in exacerbated striatal lesions, with increased neuronal loss, gliosis and nuclear fragmentation/compaction, compared to wild-type mice
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• ventricular enlargement
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cellular
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• 3-NP, a mitochondrial neurotoxin, results in exacerbated striatal lesions, with increased neuronal loss, gliosis and nuclear fragmentation/compaction, compared to wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation
(15 available);
any
Il10 mutation
(44 available)
Rps6ka4tm1Jsca mutation
(0 available);
any
Rps6ka4 mutation
(35 available)
Rps6ka5tm1Jsca mutation
(0 available);
any
Rps6ka5 mutation
(63 available)
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immune system
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• there is no IL-10 secretion from bone marrow derived macrophages after LPS stimulation
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL12a than in controls during an 8 hour time period
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL12b than in controls during an 8 hour time period
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL-6 than in controls during an 8 hour time period
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of TNF than in controls during an 8 hour time period
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6ka4tm1Jsca mutation
(0 available);
any
Rps6ka4 mutation
(35 available)
Rps6ka5tm1Jsca mutation
(0 available);
any
Rps6ka5 mutation
(63 available)
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mortality/aging
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• less mice die 48 hours after sepsis induction by cecal ligation and puncture than in control
• 40% of mice die compared to 10% of wild-type mice subjected to the same sepsis model
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immune system
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• LPS administration (1.8 mg/kg bodyweight) leads to significantly decreased levels of IL-10 four hours after administration compared to controls
• less IL-10 is also found in the plasma of mice undergoing sepsis from cecal ligation and puncture
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• LPS administration (1.8 mg/kg bodyweight) leads to significantly increased levels of IL-12a four hours after administration compared to controls
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL12b than in controls during an 8 hour time period
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• LPS administration (1.8 mg/kg bodyweight) leads to significantly increased levels of IL-6 four hours after administration compared to controls
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• LPS administration (1.8 mg/kg bodyweight) leads to significantly increased levels of TNF one hour after administration compared to controls
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• LPS stimulation of bone marrow derived macrophages leads to decreased secretion of IL-10 than in controls during an 8 hour time period
• the discrepancy is greater during the early time points; 8 hours after stimulation secretion levels have reached 60% of wild-type
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL12a than in controls during an 8 hour time period
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL12b than in controls during an 8 hour time period
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• LPS stimulation of bone marrow derived macrophages leads to higher secretion of IL-6 than in controls during an 8 hour time period
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• stimulation of bone marrow derived macrophages leads to higher secretion of TNF than in controls during an 8 hour time period
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• 2.5 mg/kg bodyweight causes LPS-induced toxicity in these mice while control mice are normal
• signs of toxicity include diarrhea, eye inflammation, piloerection, and a substantial drop in temperature within 4-8 hours of LPS injection
• mice were humanly sacrificed within 8 hours of LPS injection due to severity of symptoms
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• inflammation fails to resolve in phorbol 12-myristate 13-acetate (PMA) induced skin eczema of the ears
• ears of wild-type mice exposed to PMA swell from inflammatory infiltrate but resolve this swelling within 96 hours while mutant mice still have significant swelling 96 hours after PMA administration
• myeloperoxidase activity of ear extracts, a measure of polymorphonuclear cell recruitment, is significantly higher than controls both 72 and 96 hours after PMA administration
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homeostasis/metabolism
integument
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• inflammation fails to resolve in phorbol 12-myristate 13-acetate (PMA) induced skin eczema of the ears
• ears of wild-type mice exposed to PMA swell from inflammatory infiltrate but resolve this swelling within 96 hours while mutant mice still have significant swelling 96 hours after PMA administration
• myeloperoxidase activity of ear extracts, a measure of polymorphonuclear cell recruitment, is significantly higher than controls both 72 and 96 hours after PMA administration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6ka4tm1Jsca mutation
(0 available);
any
Rps6ka4 mutation
(35 available)
Rps6ka5tm1Jsca mutation
(0 available);
any
Rps6ka5 mutation
(63 available)
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immune system
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• T cells stimulated in vitro with anti-CD3 and anti-CD28 antibodies do not proliferate as well as wild-type cells
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• at 6 weeks, mice have a reduction in the number of cells in the spleen
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hematopoietic system
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• T cells stimulated in vitro with anti-CD3 and anti-CD28 antibodies do not proliferate as well as wild-type cells
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• at 6 weeks, mice have a reduction in the number of cells in the spleen
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cellular
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• T cells stimulated in vitro with anti-CD3 and anti-CD28 antibodies do not proliferate as well as wild-type cells
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Analysis Tools