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Allele Symbol Allele Name Allele ID |
Txnrd1tm1Marc targeted mutation 1, Marcus Conrad MGI:3574358 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• cerebellar foliation is normal
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| N |
• mice exhibit normal behavior
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| N |
• mice exhibit normal growth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• most regions of the brain including the olfactory bulb, subventricular zone and cerebral cortex are morphologically normal
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• fissure formation in the anterior cerebellum is reduced
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• only lobules VII to X form, while lobules I to VI are fused and unlaminated
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• from P1
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• there is no distinction between the molecular, Purkinje cell and granular layers in the anterior portions of the cerebellar cortex
• however, lamination of the posterior cerebellar cortex is normal
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• the dendritic trees of Purkinje cells, in the anterior more so than the posterior cerebellum, are less elaborate than in wild-type mice
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• at weaning the cerebellum is one fourth of wild-type in size
• cell proliferation is 3 times lower than normal at P7 and 2 times lower than normal at P14
• cell density in the granular layer in the anterior end is reduced
the posterior lobules are smaller
• however, apoptotic rates are normal
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• glial cells in the anterior cerebellum are disoriented
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• Bergmann glial fibers in the anterior cerebellum are shorter, disoriented and reduced in density compared to in wild-type mice
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• at P7
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• 11 of 14 times mice fail to climb down a pole in a modified pole test unlike wild-type mice
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• at P7, mice exhibit an ataxic gait
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• although of normal size at birth, within a few days mice are smaller than wild-type mice
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• by 4 weeks of age mice have only reached half the weight of wild-type mice
• mice only grow to adulthood when provided food pellets at the bottom of the cage
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| N |
• mice are fertile and able to nurse
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no differences in heart shape or in the cellular morphology of cardiomyocytes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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