All Phenotypes Nba10<NZB> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nba10^NZB
NZB
MGI:3529870

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nba10^NZB/Nba10^NZB Tlr7^tm1Aki/Y X/Yaa	B6.Cg-Nba10^NZB Tlr7^tm1Aki Yaa	MGI:3804683
cx2	Nba10^NZB/Nba10^NZB X/Yaa	C57BL/6-Nba2 Yaa	MGI:3529942
cx3	Nba10^NZB/Nba10^NZB Tg(Tnfsf13b)1Fma/0	involves: C57BL/6 * DBA/2J * NZB	MGI:3789188
ot4	Nba10^NZB/?	involves: C57BL/6 * NZB * SB/Le	MGI:3529941

Allelic Composition	Nba10^NZB/Nba10^NZB Tlr7^tm1Aki/Y X/Yaa
Genetic Background	B6.Cg-Nba10^NZB Tlr7^tm1Aki Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10^NZB mutation (1 available); any Nba10 mutation (1 available)
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (21 available)
Yaa mutation (18 available); any Yaa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased monocyte cell number ( J:137656 )

• 20% monocytosis incidence in males

• monocytosis incidence is decreased compared to C57BL/6-Nba2^NZB Yaa males (71% incidence)

abnormal immune serum protein physiology ( J:137656 )

• increased production of retroviral gp70 immune complex compared to wild-type males

increased anti-chromatin antibody level ( J:137656 )

glomerulonephritis ( J:137656 )

• 25% incidence of lethal lupus nephritis in males by 14 months of age

• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males

• increased glomerular lesion score compared to wild-type males

renal/urinary system

glomerulonephritis ( J:137656 )

• 25% incidence of lethal lupus nephritis in males by 14 months of age

• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males

• increased glomerular lesion score compared to wild-type males

hematopoietic system

increased monocyte cell number ( J:137656 )

• 20% monocytosis incidence in males

• monocytosis incidence is decreased compared to C57BL/6-Nba2^NZB Yaa males (71% incidence)

Allelic Composition	Nba10^NZB/Nba10^NZB X/Yaa
Genetic Background	C57BL/6-Nba2 Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10^NZB mutation (1 available); any Nba10 mutation (1 available)
Yaa mutation (18 available); any Yaa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased monocyte cell number ( J:129409 , J:137656 )

• CD11b⁺ monocyte numbers increase as mice age (J:129409)

• a Gr-1^- monocyte subset is the dominant subset by 10 months of age (J:129409)

• increased susceptibility to monocytosis in males (J:137656)

• 71% monocytosis incidence in males (J:137656)

increased susceptibility to type III hypersensitivity reaction ( J:95829 )

• increased serum gp70 immune complex levels

abnormal immune serum protein physiology ( J:137656 )

• increased production of serum gp70 immune complex in males

increased susceptibility to autoimmune disorder ( J:95829 )

increased autoantibody level ( J:137656 )

• increased anti-ribonucleoprotein production in males

increased anti-nuclear antigen antibody level ( J:95829 )

• increased anti-chromatin and anti-DNA antibodies

increased anti-chromatin antibody level ( J:137656 )

glomerulonephritis ( J:95829 , J:137656 )

• susceptibility to severe glomerulonephritis (J:95829)

• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)

• increased lupus nephritis score (severity) in males (J:137656)

renal/urinary system

glomerulonephritis ( J:95829 , J:137656 )

• susceptibility to severe glomerulonephritis (J:95829)

• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)

• increased lupus nephritis score (severity) in males (J:137656)

hematopoietic system

increased monocyte cell number ( J:129409 , J:137656 )

• CD11b⁺ monocyte numbers increase as mice age (J:129409)

• a Gr-1^- monocyte subset is the dominant subset by 10 months of age (J:129409)

• increased susceptibility to monocytosis in males (J:137656)

• 71% monocytosis incidence in males (J:137656)

Allelic Composition	Nba10^NZB/Nba10^NZB Tg(Tnfsf13b)1Fma/0
Genetic Background	involves: C57BL/6 * DBA/2J * NZB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10^NZB mutation (1 available); any Nba10 mutation (1 available)
Tg(Tnfsf13b)1Fma mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:134128 )

• increased total splenic B cell numbers

increased marginal zone B cell number ( J:134128 )

increased IgG level ( J:134128 )

• increased total serum IgG antibodies

increased IgM level ( J:134128 )

• increased total serum IgM antibodies

increased susceptibility to systemic lupus erythematosus ( J:134128 )

• increased serum IgG and IgM antibodies

• increased incidence of glomerulonephritis by 3 months of age

increased anti-chromatin antibody level ( J:134128 )

increased anti-double stranded DNA antibody level ( J:134128 )

• increased serum IgG anti-dsDNA Abs shows positive correlation to glomerulonephritis severity

glomerulonephritis ( J:134128 )

• increased glomerulonephritis incidence at 3 months of age

renal/urinary system

glomerulonephritis ( J:134128 )

• increased glomerulonephritis incidence at 3 months of age

hematopoietic system

increased B cell number ( J:134128 )

• increased total splenic B cell numbers

increased marginal zone B cell number ( J:134128 )

increased IgG level ( J:134128 )

• increased total serum IgG antibodies

increased IgM level ( J:134128 )

• increased total serum IgM antibodies

Allelic Composition	Nba10^NZB/?
Genetic Background	involves: C57BL/6 * NZB * SB/Le

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10^NZB mutation (1 available); any Nba10 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to type III hypersensitivity reaction ( J:95829 )

• increased serum gp70 immune complex levels

increased anti-chromatin antibody level ( J:95829 )

• increased anti-chromatin antibodies

increased anti-double stranded DNA antibody level ( J:95829 )

• increased anti-DNA antibodies

glomerulonephritis ( J:95829 )

• susceptibility to severe glomerulonephritis

renal/urinary system

glomerulonephritis ( J:95829 )

• susceptibility to severe glomerulonephritis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23