Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cl1tm1Sgs mutation
(0 available);
any
Cx3cl1 mutation
(32 available)
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nervous system
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• infarct size was reduced by 28% and significantly lower mortality was seen in homozygotes compared to wild-type mice after middle cerebral artery occlusion
• however, the brain and surface cerebral arteries are not significantly different in homozygotes compared to wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation
(33 available);
any
Apoe mutation
(145 available)
Cx3cl1tm1Sgs mutation
(0 available);
any
Cx3cl1 mutation
(32 available)
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cardiovascular system
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• brachiocephalic artery lesion area is reduced by about 85% at 200 um and 400 um but not at 600 um from its branching site into the carotid and subclavian arteries in female double homozygotes compared to Apoe single homozygotes
• in male double homozygotes brachiocephalic artery lesion area is reduced by 82% at 200 um, 58% at 400 um, and 59% at 600 um
• aortic root lesion area is reduced by about 30% in double homozygous females at 12 weeks of age but not in males at 12 weeks or in either sex at 16 weeks
• lesions are less advanced than in Apoe single homozygotes and are composed almost entirely of foam cells
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immune system
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• atherosclerotic lesions are composed almost entirely of foam cells
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• macrophage accumulation is reduced by 80% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries
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hematopoietic system
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• atherosclerotic lesions are composed almost entirely of foam cells
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• macrophage accumulation is reduced by 80% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries
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cellular
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• atherosclerotic lesions are composed almost entirely of foam cells
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• macrophage accumulation is reduced by 80% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cl1tm1Sgs mutation
(0 available);
any
Cx3cl1 mutation
(32 available)
Ldlrtm1Her mutation
(19 available);
any
Ldlr mutation
(76 available)
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cardiovascular system
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• aortic-root lesion area is reduced in females by 35% but not reduced in males
• brachiocephalic artery lesion area is reduced in female double homozygotes by about 50% at 200 um from its branching site into the carotid and subclavian arteries
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homeostasis/metabolism
immune system
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• macrophage accumulation is reduced by 57% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries
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cellular
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• macrophage accumulation is reduced by 57% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries
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hematopoietic system
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• macrophage accumulation is reduced by 57% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cl1tm1Sgs mutation
(0 available);
any
Cx3cl1 mutation
(32 available)
Ldlrtm1Her mutation
(19 available);
any
Ldlr mutation
(76 available)
|
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cardiovascular system
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• aortic-root lesion area is reduced in females by 28% but not reduced in males
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homeostasis/metabolism
Analysis Tools