All Phenotypes Traf2<tm1Rbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Traf2^tm1Rbr
targeted mutation 1, Robert Brink
MGI:3511494

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19⁺ Tnfsf13b^tm1Msc/Tnfsf13b^tm1Msc Traf2^tm1Rbr/Traf2^tm1Rbr	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3777352
cn2	Cd19^tm1(cre)Cgn/Cd19⁺ Traf2^tm1Rbr/Traf2^tm1Rbr	involves: 129P2/OlaHsd * C57BL/6	MGI:3777342
cn3	Cd19^tm1(cre)Cgn/Cd19⁺ Traf2^tm1Rbr/Traf2^tm1Rbr Traf3^tm1Rbr/Traf3^tm1Rbr	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3777347
cn4	Tg(Mx1-cre)1Cgn/0 Traf2^tm1Rbr/Traf2^tm1Rbr	involves: C57BL/6 * CBA	MGI:3511504
cn5	Tg(Lck-cre)I57Jxm/? Traf2^tm1Rbr/Traf2^tm1Rbr	involves: C57BL/6 * ICR	MGI:3777349
cx6	Tnfsf13b^tm1Msc/Tnfsf13b^tm1Msc Traf2^tm1Rbr/Traf2^tm1Rbr	involves: 129S2/SvPas * C57BL/6	MGI:3777351
cx7	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Traf2^tm1Rbr/Traf2^tm1Rbr	involves: C57BL/6	MGI:5013720

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Tnfsf13b^tm1Msc/Tnfsf13b^tm1Msc Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Tnfsf13b^tm1Msc mutation (1 available); any Tnfsf13b mutation (28 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased follicular B cell number ( J:132877 )

• there is about a 4-fold increase in the number of follicular B cells found in the spleen compared to controls

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

hematopoietic system

increased follicular B cell number ( J:132877 )

• there is about a 4-fold increase in the number of follicular B cells found in the spleen compared to controls

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased follicular B cell number ( J:132877 )

• there is almost a 2-fold increase in the number of follicular B cells found in the spleen

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

• surface expression of CD21 on these cells is enhanced

abnormal B cell physiology ( J:132877 )

• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

lymph node hyperplasia ( J:132877 )

• about a 3-fold increase in the number of cells present in lymph nodes

• increase is due to expansion of the B cell compartment

hematopoietic system

increased follicular B cell number ( J:132877 )

• there is almost a 2-fold increase in the number of follicular B cells found in the spleen

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

• surface expression of CD21 on these cells is enhanced

abnormal B cell physiology ( J:132877 )

• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Traf2^tm1Rbr/Traf2^tm1Rbr Traf3^tm1Rbr/Traf3^tm1Rbr
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

• surface expression of CD21 on these cells is enhanced

abnormal B cell physiology ( J:132877 )

• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

hematopoietic system

increased marginal zone B cell number ( J:132877 )

• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

• surface expression of CD21 on these cells is enhanced

abnormal B cell physiology ( J:132877 )

• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

Allelic Composition	Tg(Mx1-cre)1Cgn/0 Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation (7 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased B cell number ( J:93890 )

• the proportion and total number of B cells were increased in spleen and lymph nodes

abnormal spleen morphology ( J:93890 )

enlarged spleen ( J:93890 )

abnormal spleen marginal zone morphology ( J:93890 )

• the increased number of marginal zone B cells results in an expansion of the marginal zone

increased marginal zone B cell number ( J:93890 )

• the proportion and total number of marginal zone B cells was increased by 3-fold and 5- fold, respectively

immune system

increased B cell number ( J:93890 )

• the proportion and total number of B cells were increased in spleen and lymph nodes

abnormal spleen morphology ( J:93890 )

enlarged spleen ( J:93890 )

abnormal spleen marginal zone morphology ( J:93890 )

• the increased number of marginal zone B cells results in an expansion of the marginal zone

increased marginal zone B cell number ( J:93890 )

• the proportion and total number of marginal zone B cells was increased by 3-fold and 5- fold, respectively

enlarged lymph nodes ( J:93890 )

• the proportion of B cells was doubled, the total B cell numbers were increased 4-fold and B cells were increased in size in the lymph nodes

growth/size/body

enlarged spleen ( J:93890 )

Allelic Composition	Tg(Lck-cre)I57Jxm/? Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (1 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:132877 )

• mature B cells are virtually absent from the lymph nodes

absent follicular B cells ( J:132877 )

• follicular B cells are absent from the spleen

absent marginal zone B cells ( J:132877 )

• marginal zone B cells are absent from the spleen

hematopoietic system

decreased mature B cell number ( J:132877 )

• mature B cells are virtually absent from the lymph nodes

absent follicular B cells ( J:132877 )

• follicular B cells are absent from the spleen

absent marginal zone B cells ( J:132877 )

• marginal zone B cells are absent from the spleen

Allelic Composition	Tnfsf13b^tm1Msc/Tnfsf13b^tm1Msc Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13b^tm1Msc mutation (1 available); any Tnfsf13b mutation (28 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:132877 )

• mature B cells are virtually absent from the lymph nodes

absent follicular B cells ( J:132877 )

• follicular B cells are absent from the spleen

absent marginal zone B cells ( J:132877 )

• marginal zone B cells are absent from the spleen

hematopoietic system

decreased mature B cell number ( J:132877 )

• mature B cells are virtually absent from the lymph nodes

absent follicular B cells ( J:132877 )

• follicular B cells are absent from the spleen

absent marginal zone B cells ( J:132877 )

• marginal zone B cells are absent from the spleen

Allelic Composition	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Traf2^tm1Rbr/Traf2^tm1Rbr
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (14 available)
Traf2^tm1Rbr mutation (0 available); any Traf2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13c^tm1Mass homozygotes

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 5-fold lower germinal center B cells compared with wild-type mice

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

hematopoietic system

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 5-fold lower germinal center B cells compared with wild-type mice

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

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