Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Ddg mutation
(2 available);
any
Nrp1 mutation
(81 available)
Tg(Thy1-YFP)16Jrs mutation
(1 available)
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nervous system
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• basal dendrites of layer 5 cortical neurons within the neocortex were markedly diminished in length and complexity
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfbp1tm1Gvdz mutation
(0 available);
any
Fgfbp1 mutation
(18 available)
Tg(Thy1-YFP)16Jrs mutation
(1 available)
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nervous system
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• increased number of fragmented neuromuscular junctions at 12 months compared with control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfbp1tm1Gvdz mutation
(0 available);
any
Fgfbp1 mutation
(18 available)
Tg(SOD1*G93A)1Gur mutation
(4 available)
Tg(Thy1-YFP)16Jrs mutation
(1 available)
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mortality/aging
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• accelerated in female and male mice compared with Tg(SOD1*G93A)1Gur mice
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nervous system
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• fewer fully innervated neuromuscular junctions (NMJs) than in Tg(SOD1*G93A)1Gur mice with more partially and completely denervated NMJs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1C201R mutation
(2 available);
any
Gars1 mutation
(42 available)
Tg(Thy1-YFP)16Jrs mutation
(1 available)
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nervous system
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• at high magnification, but not evident at low magnification, approximately 5% of the neuromuscular junctions assesed in the levator auris longus at 4 months of age are found to be only partially innervated, far fewer than in Nmf249 heterozygotes
• nearly all terminals assessed in the levator auris longus show more diffuse postsynaptic staining, less distinct gutters, thinner axons and presynaptic nerves, synapses that are smaller than in wild-type controls, the average quantal content is significantly lower than normal, and the quantal content and mean evoked endplate currents are lower still at 4 months compared with 2 months
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• at 2 months of age 25% decrease in amplitude of evoked endplate currents, and quantal content in neuromuscular synapses of the levator auris longus muscle, and treatment with 3,4-DAP or physostigmine increases the in vivo evoked endplate currents at 4 months of age
• at 2 months of age the frequency of spontaneous release is consistently lower than normal although the quantal amplitude at synapses is normal, and no differences are found in the miniature endplate current amplitude
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behavior/neurological
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• compared with wild-type controls, heterozygotes have impaired grip strength and this is improved by treatment with physostigmine, but made worse by treatment with 3,4-DAP
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1tm1a(EUCOMM)Wtsi mutation
(1 available);
any
Dynlrb1 mutation
(12 available)
Tg(Thy1-YFP)16Jrs mutation
(1 available)
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nervous system
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• DRG neurons exhibit significantly reduced axon outgrowth after 48 h in culture
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cellular
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• DRG neurons exhibit significantly reduced axon outgrowth after 48 h in culture
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1Nmf249 mutation
(1 available);
any
Gars1 mutation
(42 available)
Tg(Thy1-YFP)16Jrs mutation
(1 available)
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nervous system
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• nearly all terminals assessed in the levator auris longus show more diffuse postsynaptic staining, less distinct gutters, thinner axons and presynaptic nerves, synapses that are smaller than in wild-type controls, fewer mitochondria at the synaptic terminals, and the average quantal content is significantly lower than normal
• at high magnification, but not evident at low magnification, approximately half of the junctions assesed in the levator auris longus at 2 months of age are found to be only partially innervated, even in the mildly affected mice, and there are more than 3 times as many denervated junctions at 2 months of age as are found in carriers of the C201R allele at 4 months of age
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• at 2 months of age 25% decrease in amplitude of evoked endplate currents, and quantal content in neuromuscular synapses the levator auris longus muscle
• at 2 months of age the frequency of spontaneous release is consistently lower than normal although the quantal amplitude at synapses is normal, and no differences are found in the miniature endplate current amplitude
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behavior/neurological
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• compared with wild-type controls, heterozygotes have impaired grip strength and this is improved by treatment with physostigmine
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Analysis Tools
