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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(FCGR2A)11Mkz
transgene insertion 11, Steven E McKenzie
MGI:3056729
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Del(1Fcgr2b-Fcgr3)1Rav/Del(1Fcgr2b-Fcgr3)1Rav
Fcgr1tm1Hoga/Fcgr1tm1Hoga
Tg(FCGR1A)#Jgjw/0
Tg(FCGR2A)11Mkz/0
Tg(FCGR2B)#Rav/0
Tg(FCGR3A)1156Rav/0
Tg(FCGR3B)1373Rav/0
involves: 129S1/Sv * C57BL/6 * CBA/Ca * FVB/N MGI:5426844
cx2
Tg(FCGR2A)11Mkz/0
Tg(PF4)#Zcy/0
involves: C57BL/6 * SJL MGI:4941606
tg3
Tg(FCGR2A)11Mkz/Tg(FCGR2A)11Mkz involves: C57BL/6 * SJL MGI:3839558
tg4
Tg(FCGR2A)11Mkz/0 involves: C57BL/6 * SJL MGI:3839538


Genotype
MGI:5426844
cx1
Allelic
Composition
Del(1Fcgr2b-Fcgr3)1Rav/Del(1Fcgr2b-Fcgr3)1Rav
Fcgr1tm1Hoga/Fcgr1tm1Hoga
Tg(FCGR1A)#Jgjw/0
Tg(FCGR2A)11Mkz/0
Tg(FCGR2B)#Rav/0
Tg(FCGR3A)1156Rav/0
Tg(FCGR3B)1373Rav/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * CBA/Ca * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1Fcgr2b-Fcgr3)1Rav mutation (0 available); any Del(1Fcgr2b-Fcgr3)1Rav mutation (0 available)
Fcgr1tm1Hoga mutation (0 available); any Fcgr1 mutation (9 available)
Tg(FCGR1A)#Jgjw mutation (0 available)
Tg(FCGR2A)11Mkz mutation (1 available)
Tg(FCGR2B)#Rav mutation (0 available)
Tg(FCGR3A)1156Rav mutation (0 available)
Tg(FCGR3B)1373Rav mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are fertile, develop normally, generate normal immune responses and do not appear to have any evidence of spontaneous pathology




Genotype
MGI:4941606
cx2
Allelic
Composition
Tg(FCGR2A)11Mkz/0
Tg(PF4)#Zcy/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(FCGR2A)11Mkz mutation (1 available)
Tg(PF4)#Zcy mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following treatment with KKO and heparin, 2 of 4 mice die unlike similarly treated single transgenic mice

hematopoietic system
• following treatment with KKO and heparin

homeostasis/metabolism
• following treatment with KKO and heparin, mice exhibit fibrin thrombi in the arterioles and capillaries in the heart, liver, lungs, and kidney compared with similarly treated single transgenic mice
• following treatment with KKO and heparin

behavior/neurological
• following treatment with KKO and heparin
• following treatment with KKO and heparin

respiratory system
• following treatment with KKO and heparin

immune system
• ollowing treatment with KKO and heparin, mice exhibit severe thrombopenia, decreased activity, rapid shallow breathing, hunched posture, and tactile hypothermia with increased lethality and fibrin thrombi in the arterioles and capillaries in the heart, liver, lungs, and kidney compared with similarly treated single transgenic mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acquired thrombocytopenia DOID:11126 J:72220




Genotype
MGI:3839558
tg3
Allelic
Composition
Tg(FCGR2A)11Mkz/Tg(FCGR2A)11Mkz
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(FCGR2A)11Mkz mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• sera IgG2a levels are elevated more than 2-fold in mice with severe spontaneous arthritis
• macrophages produce 6.5-fold more TNF in response to immunoglobulin aggregates compared to controls
• macrophages produce 6.5-fold more TNF in response to immunoglobulin aggregates compared to controls
• in mice over 20 weeks of age, 13 of 23 have anti-histone antibodies above background levels
• 32% of mice develop a spontaneous form of arthritis between 20 and 50 weeks of age
• arthritis is characterized by severe ankylosis of the tibiotarsal and tarsophalangeal cartilage, loss of joint space and prominent periarticular new bone formation
• the arthritic joints contain synovial hyperplasia and proliferation, cartilage erosion, pannus formation, and joint space infiltrate
• transgenic mice have an earlier onset of collagen-induced arthritis than controls despite having a protective H2 locus
• mean day of onset is 18 days versus 22 days in the susceptible DBA/1 strain
• 15% of mice develop arthritis with just one immunization of collagen compared to none in DBA/1 mice
• over 90% of mice develop arthritis within six days after a second injection of collagen compared to less then 10% of DBA/1 mice
• mice are also highly susceptible to an arthritis model initiated by injections of anti-collagen antibodies
• 100% of mice develop arthritis after injection of anti-collagen antibody while controls needed an LPS adjuvant in addition to the immunoglobulins to develop disease
• mice have an age-related progression to severe glomerulonephritis
• few mice have the disease prior to 20 weeks of age, up to 80% have disease by 40 weeks of age, and all mice have disease over 40 weeks of age
• disease is first evident as multifocallymphoplasmacytic infiltrate in the renal interstitium mainly around major arcuate vessels
• more advanced disease was seen, with enlarged glomeruli, increased mesangial matrix and condensation of glomerular tufts
• disease is self-limiting as kidney function is never impaired
• pneumonitis was found in 25% of mice between 12 to 40 weeks of age and increases to 100% in older mice
• disease is characterized by patches of perivascular inflammation with cellular aggregates of macrophages, lymphocytes, and plasma cells within alveolar walls
• in severe cases, up to 50% of the normal architecture of the lungs is obliterated

renal/urinary system
• mice have an age-related progression to severe glomerulonephritis
• few mice have the disease prior to 20 weeks of age, up to 80% have disease by 40 weeks of age, and all mice have disease over 40 weeks of age
• disease is first evident as multifocallymphoplasmacytic infiltrate in the renal interstitium mainly around major arcuate vessels
• more advanced disease was seen, with enlarged glomeruli, increased mesangial matrix and condensation of glomerular tufts
• disease is self-limiting as kidney function is never impaired
• immunoglobulin deposition is noted in the kidney

respiratory system
• pneumonitis was found in 25% of mice between 12 to 40 weeks of age and increases to 100% in older mice
• disease is characterized by patches of perivascular inflammation with cellular aggregates of macrophages, lymphocytes, and plasma cells within alveolar walls
• in severe cases, up to 50% of the normal architecture of the lungs is obliterated

skeleton
• 32% of mice develop a spontaneous form of arthritis between 20 and 50 weeks of age
• arthritis is characterized by severe ankylosis of the tibiotarsal and tarsophalangeal cartilage, loss of joint space and prominent periarticular new bone formation
• the arthritic joints contain synovial hyperplasia and proliferation, cartilage erosion, pannus formation, and joint space infiltrate
• transgenic mice have an earlier onset of collagen-induced arthritis than controls despite having a protective H2 locus
• mean day of onset is 18 days versus 22 days in the susceptible DBA/1 strain
• 15% of mice develop arthritis with just one immunization of collagen compared to none in DBA/1 mice
• over 90% of mice develop arthritis within six days after a second injection of collagen compared to less then 10% of DBA/1 mice
• mice are also highly susceptible to an arthritis model initiated by injections of anti-collagen antibodies
• 100% of mice develop arthritis after injection of anti-collagen antibody while controls needed an LPS adjuvant in addition to the immunoglobulins to develop disease

hematopoietic system
• sera IgG2a levels are elevated more than 2-fold in mice with severe spontaneous arthritis
• macrophages produce 6.5-fold more TNF in response to immunoglobulin aggregates compared to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:136516




Genotype
MGI:3839538
tg4
Allelic
Composition
Tg(FCGR2A)11Mkz/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(FCGR2A)11Mkz mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• severe thrombocytopenia can be induced in mice by an anti-platelet rat monoclonal antibody specific for platelets that normally induces only a mild thrombocytopenia in wild-type mice





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last database update
05/07/2019
MGI 6.14
The Jackson Laboratory