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Transgene Detail
Symbol: Tg(FCGR2A)11Mkz
Name: transgene insertion 11, Steven E McKenzie
MGI ID: MGI:3056729
Synonyms: FcgammaRIIATGN, huFCGR2AR131
Transgene: Tg(FCGR2A)11Mkz  Location: unknown  
Alliance: Tg(FCGR2A)11Mkz page
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(FCGR2A)11Mkz expresses 1 gene
Mutation detailsThe transgene contains the human FCGR2A gene. The genomic clone used in the transgene encodes the R131 polymorphic form of human FcgRIIA, which binds the widest range of mouse IgG subclasses including mouse IgG1 and rat IgG2a as well. 10 copies of the transgene was estimated to have inserted into the genome. Transgenic mice express human FCGR2A on mouse platelets and macrophages at levels equivalent to that observed in human cells. (J:93244, J:136516)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:93244 McKenzie SE, et al., The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol. 1999 May 1;162(7):4311-8
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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