Tg(FCGR2A)11Mkz
Transgene Detail
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Symbol: |
Tg(FCGR2A)11Mkz |
Name: |
transgene insertion 11, Steven E McKenzie |
MGI ID: |
MGI:3056729 |
Synonyms: |
FcgammaRIIATGN, huFCGR2AR131 |
Transgene: |
Tg(FCGR2A)11Mkz Location: unknown
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Alliance: |
Tg(FCGR2A)11Mkz page
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Strain of Origin: |
(C57BL/6 x SJL)F2
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(FCGR2A)11Mkz expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
FCGR2A (2212) |
Fcgr3 |
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Mutation details: The transgene contains the human FCGR2A gene. The genomic clone used in the transgene encodes the R131 polymorphic form of human FcgRIIA, which binds the widest range of mouse IgG subclasses including mouse IgG1 and rat IgG2a as well. 10 copies of the transgene was estimated to have inserted into the genome. Transgenic mice express human FCGR2A on mouse platelets and macrophages at levels equivalent to that observed in human cells.
(J:93244, J:136516)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:93244 McKenzie SE, et al., The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol. 1999 May 1;162(7):4311-8 |
All: |
41 reference(s) |
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