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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Disp1tm1Amc
targeted mutation 1, Andrew P McMahon
MGI:3052133
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Disp1tm1Amc/Disp1tm1Amc involves: 129X1/SvJ MGI:3052722
ht2
Disp1icb/Disp1tm1Amc involves: 129X1/SvJ * C57BL/6J MGI:3052725
cn3
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3054017
cx4
Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ MGI:3052724
cx5
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3052728


Genotype
MGI:3052722
hm1
Allelic
Composition
Disp1tm1Amc/Disp1tm1Amc
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at birth, difficulty breathing (J:92058)
• die at birth, difficulty breathing (J:92058)

craniofacial
• loss of primary palate (J:92058)
• loss of primary palate (J:92058)
• mild midline facial defects involving the nose and upper jaw (J:92058)
• mild midline facial defects involving the nose and upper jaw (J:92058)
• hypoplastic philtrum (J:92058)
• hypoplastic philtrum (J:92058)
• loss of upper incisors (J:92058)
• loss of upper incisors (J:92058)
• fused vomeronasal organs (J:92058)
• fused vomeronasal organs (J:92058)

endocrine/exocrine glands

respiratory system
• fused vomeronasal organs (J:92058)
• fused vomeronasal organs (J:92058)
• nasopharyngeal airway narrowed or closed (J:92058)
• nasopharyngeal airway narrowed or closed (J:92058)
• difficulty breathing at birth leading to death (J:92058)
• difficulty breathing at birth leading to death (J:92058)

skeleton
• loss of primary palate (J:92058)
• loss of primary palate (J:92058)

nervous system
• fused vomeronasal organs (J:92058)
• fused vomeronasal organs (J:92058)
• 40% reduction of progenitor V3 population (J:92058)
• 40% reduction of progenitor V3 population (J:92058)

vision/eye
• eyes positioned near the midline (J:92058)
• eyes positioned near the midline (J:92058)

growth/size/body
• mild midline facial defects involving the nose and upper jaw (J:92058)
• mild midline facial defects involving the nose and upper jaw (J:92058)
• hypoplastic philtrum (J:92058)
• hypoplastic philtrum (J:92058)
• loss of upper incisors (J:92058)
• loss of upper incisors (J:92058)
• fused vomeronasal organs (J:92058)
• fused vomeronasal organs (J:92058)




Genotype
MGI:3052725
ht2
Allelic
Composition
Disp1icb/Disp1tm1Amc
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• severe losses of frontal component (J:92058)
• severe losses of frontal component (J:92058)
• loss of upper incisors (J:92058)
• loss of upper incisors (J:92058)
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)

endocrine/exocrine glands
• failed to develop (J:92058)
• failed to develop (J:92058)

respiratory system
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)
• nasopharyngeal airway narrowed or closed (J:92058)
• nasopharyngeal airway narrowed or closed (J:92058)

skeleton
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• severe losses of frontal component (J:92058)
• severe losses of frontal component (J:92058)
• delayed differentiation in the cervical region (J:92058)
• delayed differentiation in the cervical region (J:92058)

nervous system
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)
• failed to develop (J:92058)
• failed to develop (J:92058)

growth/size/body
• severe midline facial defects by E10.5 (J:92058)
• severe midline facial defects by E10.5 (J:92058)
• loss of upper incisors (J:92058)
• loss of upper incisors (J:92058)
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)




Genotype
MGI:3054017
cn3
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digit 2 is absent, all other digits are present (J:92504)
• digit 2 is absent, all other digits are present (J:92504)




Genotype
MGI:3052724
cx4
Allelic
Composition
Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable fertile, and outwardly normal (J:92058)
• viable fertile, and outwardly normal (J:92058)

nervous system
N
• normal floor plate and progenitor/precursor neuron patterning (J:92058)
• normal floor plate and progenitor/precursor neuron patterning (J:92058)




Genotype
MGI:3052728
cx5
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
Shhtm1Amc mutation (1 available); any Shh mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• no heart looping but normal embryo turning (J:92058)
• no heart looping but normal embryo turning (J:92058)

nervous system
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors (J:92058)
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors (J:92058)

craniofacial
• extreme proboscis-like nasal process (J:92058)
• extreme proboscis-like nasal process (J:92058)

growth/size/body
• extreme proboscis-like nasal process (J:92058)
• extreme proboscis-like nasal process (J:92058)

Mouse Models of Human Disease
OMIM ID Ref(s)
Holoprosencephaly 3; HPE3 142945 J:92058





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory