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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Disp1tm1Amc
targeted mutation 1, Andrew P McMahon
MGI:3052133
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Disp1tm1Amc/Disp1tm1Amc involves: 129X1/SvJ MGI:3052722
ht2
Disp1icb/Disp1tm1Amc involves: 129X1/SvJ * C57BL/6J MGI:3052725
cn3
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3054017
cx4
Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ MGI:3052724
cx5
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3052728


Genotype
MGI:3052722
hm1
Allelic
Composition
Disp1tm1Amc/Disp1tm1Amc
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at birth, difficulty breathing

craniofacial
• loss of primary palate
• loss of upper incisors
• mild midline facial defects involving the nose and upper jaw
• hypoplastic philtrum
• fused vomeronasal organs

endocrine/exocrine glands

respiratory system
• fused vomeronasal organs
• nasopharyngeal airway narrowed or closed
• difficulty breathing at birth leading to death

skeleton
• loss of primary palate
• loss of upper incisors

nervous system
• fused vomeronasal organs
• 40% reduction of progenitor V3 population

vision/eye
• eyes positioned near the midline

growth/size/body
• mild midline facial defects involving the nose and upper jaw
• loss of upper incisors
• hypoplastic philtrum
• fused vomeronasal organs




Genotype
MGI:3052725
ht2
Allelic
Composition
Disp1icb/Disp1tm1Amc
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (26 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• misshapen or absent
• misshapen or absent
• loss of primary palate, premaxillary and nasal components
• severe losses of frontal component
• loss of upper incisors
• lack vomeronasal organs

endocrine/exocrine glands
• failed to develop

respiratory system
• lack vomeronasal organs
• nasopharyngeal airway narrowed or closed

skeleton
• misshapen or absent
• misshapen or absent
• loss of primary palate, premaxillary and nasal components
• severe losses of frontal component
• loss of upper incisors
• delayed differentiation in the cervical region

nervous system
• lack vomeronasal organs
• failed to develop

growth/size/body
• severe midline facial defects by E10.5
• loss of upper incisors
• lack vomeronasal organs




Genotype
MGI:3054017
cn3
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (26 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (26 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digit 2 is absent, all other digits are present




Genotype
MGI:3052724
cx4
Allelic
Composition
Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Amc mutation (0 available); any Disp1 mutation (26 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable fertile, and outwardly normal

nervous system
N
• normal floor plate and progenitor/precursor neuron patterning




Genotype
MGI:3052728
cx5
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (26 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (26 available)
Shhtm1Amc mutation (1 available); any Shh mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• no heart looping but normal embryo turning

nervous system
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors

craniofacial
• extreme proboscis-like nasal process

growth/size/body
• extreme proboscis-like nasal process

Mouse Models of Human Disease
OMIM ID Ref(s)
Holoprosencephaly 3; HPE3 142945 J:92058





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory