Phenotypes associated with this allele
nervous system
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• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm3.1(Zfp423*)Reed mutation
(0 available);
any
Ebf2 mutation
(30 available)
Or8a1btm4Mom mutation
(1 available);
any
Or8a1b mutation
(35 available)
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nervous system
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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• some labeled axons innervate aberrant extra glomeruli in the olfactory bulb
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craniofacial
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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respiratory system
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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taste/olfaction
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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growth/size/body
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm4Mom mutation
(1 available);
any
Or8a1b mutation
(35 available)
Ttc8tm1Reed mutation
(0 available);
any
Ttc8 mutation
(34 available)
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Olfactory sensory neurons axon targeting is perturbed in Ttc8tm1Reed/Ttc8tm1Reed Or8a1btm4Mom/Or8a1b+ mice
nervous system
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• impaired fasiculation of olfactory sensory neuron axons
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• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed
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cellular
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• impaired fasiculation of olfactory sensory neuron axons
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• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed
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Allelic
Composition |
Ebf2tm1Reed/Ebf2+
Or8a1btm4Mom/Or8a1b+
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Genetic
Background |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm1Reed mutation
(0 available);
any
Ebf2 mutation
(30 available)
Or8a1btm4Mom mutation
(1 available);
any
Or8a1b mutation
(35 available)
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nervous system
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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craniofacial
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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respiratory system
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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taste/olfaction
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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growth/size/body
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy3tm1Drs mutation
(0 available);
any
Adcy3 mutation
(42 available)
Or8a1btm4Mom mutation
(1 available);
any
Or8a1b mutation
(35 available)
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nervous system
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• glomeruli structure is irregular
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• on the median and lateral sides of the bulb, fewer Olfr160+ neurons form large glomeruli as in wild-type mice
• fewer Olfr160+ neurons are present (197+/-40 compared to 213+/-51 in wild-type mice)
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nervous system
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• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character
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• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character
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nervous system
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb
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craniofacial
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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respiratory system
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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taste/olfaction
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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growth/size/body
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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nervous system
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb
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craniofacial
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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respiratory system
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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taste/olfaction
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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growth/size/body
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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Analysis Tools
