All Phenotypes Cd274<tm1Shr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd274^tm1Shr
targeted mutation 1, Arlene H Sharpe
MGI:3050803

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd274^tm1Shr/Cd274^tm1Shr	C.B6-Cd274^tm1Shr	MGI:3721514
hm2	Cd274^tm1Shr/Cd274^tm1Shr	involves: C57BL/6	MGI:3051544
cx3	Cd274^tm1Shr/Cd274^tm1Shr Pdcd1lg2^tm3Shr/Pdcd1lg2^tm3Shr	C.B6-Cd274^tm1Shr Pdcd1lg2^tm3Shr	MGI:3721513
cx4	Cd274^tm1Shr/Cd274^tm1Shr Tg(TcraTcrb)1100Mjb/0	involves: C57BL/6	MGI:4397688

Allelic Composition	Cd274^tm1Shr/Cd274^tm1Shr
Genetic Background	C.B6-Cd274^tm1Shr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274^tm1Shr mutation (2 available); any Cd274 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased interferon-gamma secretion ( J:123785 )

• in an adoptive transfer experiment into mice, DO11 transgenic T cells are modestly stimulated to over-produce interferon-gamma

abnormal interleukin secretion ( J:123785 )

• in an adoptive transfer experiment into mice, DO11 transgenic T cells are modestly stimulated to over-produce IL-2

• in an adoptive transfer experiment into mice, IL-4+ DO11 transgenic cells are reduced by 56%

increased susceptibility to autoimmune diabetes ( J:123785 )

• onset of automimmune diabetes mellitus is accelerated, sex-specific disease progression is lost, and penetrance is complete similar to in Pdcd1lg2^tm3Shr homozygotes

Allelic Composition	Cd274^tm1Shr/Cd274^tm1Shr
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274^tm1Shr mutation (2 available); any Cd274 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:91480 )

• when stimulated with low concentrations of anti CD3, CD4+ cells produce increased amounts of IFN-gamma

• when stimulated with high concentrations of anti CD3, IFN-gamma response was comparable to controls

abnormal CD8-positive, alpha beta T cell morphology ( J:91480 )

• IFN-gamma produced at increased levels when cells are stimulate with high levels of antibody

• at low levels of antibody cells produce undetectable levels of IFN-gamma, even in controls

• Cd8+ cell expansion is increased after stimulation with high antibody levels

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:91480 )

• when stimulated with low concentrations of anti CD3, CD4+ cells produce increased amounts of IFN-gamma

• when stimulated with high concentrations of anti CD3, IFN-gamma response was comparable to controls

abnormal CD8-positive, alpha beta T cell morphology ( J:91480 )

• IFN-gamma produced at increased levels when cells are stimulate with high levels of antibody

• at low levels of antibody cells produce undetectable levels of IFN-gamma, even in controls

• Cd8+ cell expansion is increased after stimulation with high antibody levels

Allelic Composition	Cd274^tm1Shr/Cd274^tm1Shr Pdcd1lg2^tm3Shr/Pdcd1lg2^tm3Shr
Genetic Background	C.B6-Cd274^tm1Shr Pdcd1lg2^tm3Shr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274^tm1Shr mutation (2 available); any Cd274 mutation (71 available)
Pdcd1lg2^tm3Shr mutation (0 available); any Pdcd1lg2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:123785 )

• bone marrow dendritic cells increases the production of IL-2 and interferon-gamma from DO11 transgenic T cells in vitro by 300% to 400% when compared to wild-type cells

increased interferon-gamma secretion ( J:123785 )

• in an in vitro assay with dendritic cell or an adoptive transfer experiment into mice, DO11 transgenic T cells are stimulated to over-produce interferon-gamma

increased interleukin-2 secretion ( J:123785 )

• in an in vitro assay with dendritic cell or an adoptive transfer experiment into mice, DO11 transgenic T cells are stimulated to over-produce IL-2

decreased interleukin-4 secretion ( J:123785 )

• bone marrow dendritic cells fail to stimulate the production of IL-4 from DO11 T cells in vitro or in adoptive transfer experiments

• in an adoptive transfer experiment into mice, IL-4+ DO11 transgenic cells are reduced by 86%

Allelic Composition	Cd274^tm1Shr/Cd274^tm1Shr Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274^tm1Shr mutation (2 available); any Cd274 mutation (71 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:153040 )

• following adoptive transfer, T cells induce rapid onset of diabetes in RIP-ova^high recipients within 1 to 3 weeks unlike similarly treated wild-type cells

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