Phenotypes associated with this allele

• Allele Symbol: Csk^tm2Tara
• Allele Name: targeted mutation 2, Alexander Tarakhovsky
• Allele ID: MGI:3050294
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Csk^tm1Tara/Csk^tm2Tara Elane^tm1(cre)Roes/Elane^+	involves: 129P2/OlaHsd * CB20 * C57BL/6	MGI:3050324

Genotype
MGI:3050324

cn1

• Allelic Composition: Csk^tm1Tara/Csk^tm2Tara; Elane^tm1(cre)Roes/Elane⁺
• Genetic Background: involves: 129P2/OlaHsd * CB20 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal myelopoiesis ( J:89716 )

• increased myelopoietic activity in bone marrow

abnormal granulocyte physiology ( J:89716 )

• increased cell adhesion

immune system

abnormal myelopoiesis ( J:89716 )

• increased myelopoietic activity in bone marrow

abnormal granulocyte physiology ( J:89716 )

• increased cell adhesion

increased acute inflammation ( J:89716 )

• inflammatory disorder in almost all mice after 6 weeks of age of CD4

• dermatitis-like symptomes

• inflammation of eyelids and ears

• acute pulmonary inflammation and perivascular accumulation of polymorphonuclear granulocytes

• granulocytic infiltration of dorsal deep dermis and subcutis of extremities

increased susceptibility to bacterial infection ( J:89716 )

• increased sensitivity to lipopolysaccharide