Mouse Genome Informatics
hm1
    Park2tm1Tmd/Park2tm1Tmd
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Decrease in tyrosine hydroxylase (TH) containing neurons in the locus coeruleus (LC) of Park2tm1Tmd/Park2tm1Tmd mice

behavior/neurological
• the acoustic startle reflex is significantly decreased

nervous system
• a reduction in dopamine neuron number is seen in the locus coeruleus by 2 months of age

homeostasis/metabolism
• norepinephrine levels are reduced in the locus coeruleus, olfactory bulb, and spinal cord but not in the cerebral cortex, brainstem, prefrontal cortex, hippocampus, diencephalon, and cerebellum of homozygous mutants compared to wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:91487