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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Park2tm1Tmd
targeted mutation 1, Ted M Dawson
MGI:3050230
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Park2tm1Tmd/Park2tm1Tmd involves: C57BL/6 MGI:3050555


Genotype
MGI:3050555
hm1
Allelic
Composition
Park2tm1Tmd/Park2tm1Tmd
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park2tm1Tmd mutation (0 available); any Park2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decrease in tyrosine hydroxylase (TH) containing neurons in the locus coeruleus (LC) of Park2tm1Tmd/Park2tm1Tmd mice

behavior/neurological
• the acoustic startle reflex is significantly decreased

nervous system
• a reduction in dopamine neuron number is seen in the locus coeruleus by 2 months of age

homeostasis/metabolism
• norepinephrine levels are reduced in the locus coeruleus, olfactory bulb, and spinal cord but not in the cerebral cortex, brainstem, prefrontal cortex, hippocampus, diencephalon, and cerebellum of homozygous mutants compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2 600116 J:91487





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory