All Phenotypes Pycard<tm1Vmd> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pycard^tm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:3046932

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pycard^tm1Vmd/Pycard^tm1Vmd	B6.129-Pycard^tm1Vmd	MGI:5428937
hm2	Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ	MGI:3625289
hm3	Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5467383
hm4	Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:3047277
cn5	Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce}/Gt(ROSA)26Sor⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺ Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6196858
cx6	Nlrp1a^Neut1/Nlrp1a^Neut1 Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5474286

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	B6.129-Pycard^tm1Vmd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:160545 )

• improved bone marrow derived macrophage viability following infection with F. tularensis

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

increased interferon-beta secretion ( J:160545 )

• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3

decreased interleukin-1 beta secretion ( J:160545 , J:193522 )

• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium or dsDNA (J:160545)

• bone marrow derived macrophages do not secrete IL1B in response to F. tularensis (J:160545)

• from LPS-primed bone marrow-derived macrophages stimulated with E. coli, C. rodentium, C. cholera and CTB (J:193522)

increased tumor necrosis factor secretion ( J:160545 )

• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3

decreased susceptibility to endotoxin shock ( J:193522 )

• mice treated with LPS challenge in a model of acute septic shock exhibit reduced serum levels of IL1b and IL18 compared with controls

• however, mice do not survive beyond 20 hours and serum levels of IL1a are increased

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

hematopoietic system

abnormal macrophage physiology ( J:160545 )

• improved bone marrow derived macrophage viability following infection with F. tularensis

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:106976 , J:124226 )

• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-1beta when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+ (J:106976)

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), IL-1-beta release from peritoneal macrophages is impaired (J:124226)

decreased interleukin-18 secretion ( J:106976 )

• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+

abnormal response to infection ( J:106976 )

• macrophages from null mice show reduced or undetectable Il-1beta release and caspase-1 activation in culture when infected with Salmonella or Francisella and reduced or undetectable Il-18 release upon infection with Salmonella, S. aureus, Francisella or Listeria compared to wild-type macrophages

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:191239 )

N	• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit normal skin tumor formation

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 alpha secretion ( J:91292 )

• reduced release of Il1 alpha from toll-like receptor primed macrophage

decreased interleukin-1 beta secretion ( J:91292 )

• reduced release of Il1 beta from toll-like receptor primed macrophage

• significantly decreased production of Il-1beta in response to Salmonella typhimurium infection

decreased interleukin-18 secretion ( J:91292 )

• reduced release of Il18 from toll-like receptor primed macrophage

decreased inflammatory response ( J:91292 )

• enhanced survival after injection with normally lethal doses of lipopolysaccharide

Allelic Composition	Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce}/Gt(ROSA)26Sor⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺ Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:260047 )

N	• mice show normal weight gain at 10 weeks of age

homeostasis/metabolism

increased circulating interferon-gamma level ( J:260047 )

• slight increase in IFN-gamma levels

increased circulating interleukin-6 level ( J:260047 )

• slight increase in IL-6 levels

increased circulating tumor necrosis factor level ( J:260047 )

• slight increase in TNF levels

immune system

immune system phenotype ( J:260047 )

N	• mice show no joint inflammation at 10 weeks of age, cytokine levels (such as IL-1 alpha, IL-1 beta, and MCP-1) are severely reduced, and the autoinflammatory disease seen in Gt(ROSA)26Sor^{tm1(OVAL/fla-GFP)Vnce} and Lyz2^tm1(cre)Ifo expressing mice is almost entirely ameliorated

increased circulating interferon-gamma level ( J:260047 )

• slight increase in IFN-gamma levels

increased circulating interleukin-6 level ( J:260047 )

• slight increase in IL-6 levels

increased circulating tumor necrosis factor level ( J:260047 )

• slight increase in TNF levels

Allelic Composition	Nlrp1a^Neut1/Nlrp1a^Neut1 Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased neutrophil cell number ( J:191055 )

immune system

increased neutrophil cell number ( J:191055 )

abnormal inflammatory response ( J:191055 )

• lethal systemic inflammatory disease

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23