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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rhotm2(RHO/GFP)Jhw
targeted mutation 2, John H Wilson
MGI:3046186
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB) MGI:3046194
hm2
Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw involves: 129S7/SvEvBrd MGI:3836175
ht3
Rhotm2(RHO/GFP)Jhw/Rho+ either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB) MGI:3046195
cx4
Pde6brd1/Pde6brd1
Rhotm2(RHO/GFP)Jhw/Rho+
either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB) MGI:3046197


Genotype
MGI:3046194
hm1
Allelic
Composition
Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm2(RHO/GFP)Jhw mutation (0 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• retinas begin to degenerate within a 3-5 months after birth
• retinal degeneration is not as severe as in Rhotm3Jhw homozygote




Genotype
MGI:3836175
hm2
Allelic
Composition
Rhotm2(RHO/GFP)Jhw/Rhotm2(RHO/GFP)Jhw
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm2(RHO/GFP)Jhw mutation (0 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the outer and inner segment boundaries are difficult to distinguish at 3, 6, and 8 weeks
• at 2 weeks, nascent rod outer segments exhibit non-uniform clumps unlike in wild-type mice
• whether light/dark reared or dark-only reared

nervous system
• the outer and inner segment boundaries are difficult to distinguish at 3, 6, and 8 weeks
• at 2 weeks, nascent rod outer segments exhibit non-uniform clumps unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:128212




Genotype
MGI:3046195
ht3
Allelic
Composition
Rhotm2(RHO/GFP)Jhw/Rho+
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm2(RHO/GFP)Jhw mutation (0 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mild retinal degeneration is seen with the number of nuclei in the outer nuclear layer being reduced to about 50% wild-type




Genotype
MGI:3046197
cx4
Allelic
Composition
Pde6brd1/Pde6brd1
Rhotm2(RHO/GFP)Jhw/Rho+
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6brd1 mutation (41 available); any Pde6b mutation (101 available)
Rhotm2(RHO/GFP)Jhw mutation (0 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• retinas begin to degenerate within 9 days after birth
• GFP expression can clearly be seen as the retinas degenerate





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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory