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hm1
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Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129S6/SvEvTac |
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• the epidermis of mutant mice is thinner with fewer proliferating cells in the basal layer compared to wild-type littermates
• treatment with oxysterol does not result in thickening of the epidermis unlike in wild-type littermates and Nr1h3tm1Djm homozygotes
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hm2
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Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129S6/SvEvTac * C57BL/6 |
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• mice succumb to infection of Listeria monocytogenes 2-3 days earlier than controls
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• occasionally mothers fail to expulse pups from uterine horns leading rarely to death
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• mice succumb to infection of Listeria monocytogenes 2-3 days earlier than controls
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• proliferation of male germ cells is significantly decreased compared to controls
(J:120913)
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• Sertoli cells have vacuoles containing cholesterol esters
(J:120913)
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• vacuoles filled with cholesterol esters are present within the myoctes
(J:120923)
• concentration of cholesterol esters are about 25-fold higher at 3 and 12 months of age
(J:120923)
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• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
(J:120923)
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• myometrium muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
(J:120923)
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• Sertoli cells have vacuoles containing cholesterol esters
(J:120913)
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• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
|
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• myometrium (uterus) muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
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• proliferation of male germ cells is significantly decreased compared to controls
(J:120913)
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cx3
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Nr1h2tm1Djm/Nr1h2tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm involves: 129S6/SvEvTac |
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• hepatic cholesterol levels are 4-fold higher than controls in mice fed a 0.2% cholesterol diet
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• hepatic cholesterol levels are 4-fold higher than controls in mice fed a 0.2% cholesterol diet
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cx4
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Npc1m1N/Npc1m1N Nr1h2tm1Djm/Nr1h2tm1Djm involves: 129S6/SvEvTac * BALB/c |
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• mice die between 60 and 90 days of age from neurodegenerative disease, which is significantly faster than Npc1 mutants on a wild-type background
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Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Niemann-Pick Disease, Type C1; NPC1 | 257220 | J:130969 | |
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cx5
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Nr1h2tm1Djm/Nr1h2tm1Djm Tg(APPswe,PSEN1dE9)85Dbo/0 involves: 129S6/SvEvTac * C3H * C57BL/6 |
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• a significant increase in cortical the Abeta1-40 plaque number is seen in mice at 32 weeks of age compared transgenic mice on a wild-type background
• plaques are also increased in size
• there is also a significant increase in Abeta1-42 plaque number at this age
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• a significant increase in cortical the Abeta1-40 plaque number is seen in mice at 32 weeks of age compared transgenic mice on a wild-type background
• plaques are also increased in size
• there is also a significant increase in Abeta1-42 plaque number at this age
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cx6
|
Nr1h2tm1Djm/Nr1h2tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm involves: 129S6/SvEvTac * C57BL/6 |
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• all mice die when given 104 CFU of Listeria monocytogenes compared to all wild-type controls surviving
• at higher doses mice succumb to the infection 2-3 days earlier than controls
|
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• occasionally mothers fail to expulse pups from uterine horns leading rarely to death
|
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• proliferation of male germ cells is significantly decreased compared to controls
(J:120913)
|
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(J:120923)
|
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• vacuoles filled with cholesterol esters are present within the myoctes
(J:120923)
• concentration of cholesterol esters are 32-fold higher at 3 months of age and 66-fold higher at 12 months of age
(J:120923)
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(J:120923)
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• 20-30% of 5.5 month old males have abnormal tubules with cellular aggregates clumping in the middle without any spermatozoa
(J:120913)
• by 10 months of age, most tubules are empty without any spermatozoa
(J:120913)
|
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• Leydig cells in mice 3.5 months of age are enlarged
(J:120913)
|
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• Sertoli cells have vacuoles filled with cholesterol esters within in them
(J:120913)
|
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• by 12 months of age, seminiferous tubules are degraded from deposits cholesterol
(J:120913)
|
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• a significant decline in testis weight is noted starting at 9 weeks of age
(J:120913)
|
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• as mice age, testis lose weight and morphology of the glands becomes becomes disrupted by cholesterol deposits
(J:120913)
|
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(J:120923)
|
|
|
• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
(J:120923)
|
|
|
• myometrium muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
(J:120923)
|
|
|
(J:120923)
|
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• apoptosis of germ cells within seminiferous tubules is more than double that of controls
(J:120913)
• ratio of proliferating/apoptotic male germ cells is significantly decreased compared to controls
(J:120913)
|
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• male mice start exhibiting fertility problems around 5 months of age with complete loss of fertility occurring by 7 months of age
(J:120913)
• the fertility problems exhibited at 5 months of age include only 55% of mated females exhibiting vaginal plugs and dramatic reductions in litter size
(J:120913)
|
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• testosterone production in the testes is significantly reduced compared to controls
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• plasma LH levels are almost half that of controls
|
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• occasionally mothers fail to expulse pups from uterine horns leading to hind-limb paralysis and rarely to death
|
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• peritoneal macrophages have a 2.7-fold increase in free cholesterol and a
2.4-fold increase in total cholesterol
|
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• all mice die when given 104 CFU of Listeria monocytogenes compared to all wild-type controls surviving
• at higher doses mice succumb to the infection 2-3 days earlier than controls
|
|
• myometrium (uterus) muscle has lower amplitudes of contraction compared to controls in response to pharmacological levels of oxytocin
|
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• peritoneal macrophages have a 2.7-fold increase in free cholesterol and a
2.4-fold increase in total cholesterol
|
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• when bone marrow is transferred into irradiated Apoe-null mice, bone marrow cells fail to lower total serum cholesterol levels as wild-type bone marrow cells do
• aortas from these mice have 3- to 8-fold more atherosclerotic lesions than Apoe-null mice receiving wild-type bone marrow
• increased atherosclerotic lesions are also observed when mutant bone marrow is transferred into LDLR-null mice
• spleens of recipient LDLR-null mice are also enlarged
|
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• 20-30% of 5.5 month old males have abnormal tubules with cellular aggregates clumping in the middle without any spermatozoa
(J:120913)
• by 10 months of age, most tubules are empty without any spermatozoa
(J:120913)
|
|
|
• Leydig cells in mice 3.5 months of age are enlarged
(J:120913)
|
|
|
• Sertoli cells have vacuoles filled with cholesterol esters within in them
(J:120913)
|
|
|
• by 12 months of age, seminiferous tubules are degraded from deposits cholesterol
(J:120913)
|
|
|
• a significant decline in testis weight is noted starting at 9 weeks of age
(J:120913)
|
|
|
• as mice age, testis lose weight and morphology of the glands becomes becomes disrupted by cholesterol deposits
(J:120913)
|
|
|
• apoptosis of germ cells within seminiferous tubules is more than double that of controls
(J:120913)
• ratio of proliferating/apoptotic male germ cells is significantly decreased compared to controls
(J:120913)
|
|
|
• proliferation of male germ cells is significantly decreased compared to controls
(J:120913)
|