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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdkn1atm1(HBsAg)Xya
targeted mutation 1, Xiao Yang
MGI:3039362
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdkn1atm1(HBsAg)Xya/Cdkn1atm1(HBsAg)Xya either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) MGI:3046807
ht2
Cdkn1atm1(HBsAg)Xya/Cdkn1a+ either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) MGI:3046834


Genotype
MGI:3046807
hm1
Allelic
Composition
Cdkn1atm1(HBsAg)Xya/Cdkn1atm1(HBsAg)Xya
Genetic
Background
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1(HBsAg)Xya mutation (0 available); any Cdkn1a mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• hepatocellular carcinoma (HCC) observed in 72.7% of male mice between 15 and 24 months of age, but not in any female mice of the same age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

liver/biliary system
• observed in some mice
• hepatocellular carcinoma (HCC) observed in 72.7% of male mice between 15 and 24 months of age, but not in any female mice of the same age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:88078




Genotype
MGI:3046834
ht2
Allelic
Composition
Cdkn1atm1(HBsAg)Xya/Cdkn1a+
Genetic
Background
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1(HBsAg)Xya mutation (0 available); any Cdkn1a mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

liver/biliary system
• observed in some mice
• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:88078





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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory