All Phenotypes Il4/Il13<tm3Anjm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm	C.129P2/OlaHsd-Il4/Il13^tm3Anjm	MGI:3850557
hm2	Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm	C.Cg-Il4/Il13^tm3Anjm	MGI:3038330
hm3	Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm	involves: 129P2/OlaHsd * BALB/c	MGI:4838263
hm4	Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm	involves: 129P2/OlaHsd * C57BL/6	MGI:3038326

Allelic Composition	Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm
Genetic Background	C.129P2/OlaHsd-Il4/Il13^tm3Anjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4/Il13^tm3Anjm mutation (1 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgE level ( J:91403 )

• less antigen-specific IgE is made compared to controls during an induced airway hyperresponsiveness model

increased IgG2a level ( J:91403 )

• more antigen-specific IgG2a is made compared to controls during an induced airway hyperresponsiveness model

decreased interferon-gamma secretion ( J:91403 )

• lymphocytes from mice sensitized and challenged with OVA produce less IFN-gamma than controls

decreased interleukin-13 secretion ( J:91403 )

• lymphocytes fail to produce IL-13

abnormal interleukin-4 secretion ( J:91403 )

• lymphocytes fail to produce IL-4

decreased interleukin-5 secretion ( J:91403 )

• lymphocytes from mice sensitized and challenged with OVA produce less IL-5 than controls

decreased susceptibility to autoimmune disorder ( J:91403 )

• mice fail to develop airway hyperresponsiveness after first being sensitized and challenged with OVA peptide

• in these mice, inflammation with eosinophil infiltrates occurs in the airways but there is a conspicuous absence of mucosal production

hematopoietic system

decreased IgE level ( J:91403 )

• less antigen-specific IgE is made compared to controls during an induced airway hyperresponsiveness model

increased IgG2a level ( J:91403 )

• more antigen-specific IgG2a is made compared to controls during an induced airway hyperresponsiveness model

Allelic Composition	Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm
Genetic Background	C.Cg-Il4/Il13^tm3Anjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4/Il13^tm3Anjm mutation (1 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:88681 )

• decreased pulmonary fibrosis is seen after FITC treatment most likely a result of an overall decrease in collagen production

Allelic Composition	Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4/Il13^tm3Anjm mutation (1 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice

immune system

ileum inflammation ( J:60609 )

• marked distension and inflammation of the ileum in S. mansoni infected mice

• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut

• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice

decreased IgG1 level ( J:178986 )

• in an anti-NP response

abnormal splenocyte physiology ( J:60609 )

• splenocytes from S. mansoni infected mice exposed to soluble schistosome egg antigens in vitro display a type 1 cytokine dominated response with marked elevation of IFNG secretion in contrast to wild-type cells that display a type 2 cytokine response

decreased inflammatory response ( J:60609 , J:165513 )

• striking reduction in granuloma development in the liver following infection with Schistosoma mansoni and granulomas that do form are virtually devoid of the characteristic eosinophil infiltration present in wild-type controls (J:60609)

• papain-induced airway eosinophilia is impaired compared to in wild-type mice (J:165513)

abnormal susceptibility to infection ( J:60609 , J:131994 )

• reduced periportal and hepatic fibrosis following infection with Schistosoma mansoni compared to wild-type mice (J:60609)

• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice (J:60609)

• mice immunized with recombinant vvG (vaccinia virus expressing the G protein of respiratory syncytial virus (RSV)) then challenged with RSV display lower percentages and total numbers of eosinophils in the bronchoalveolar lavage (BAL) compared to wild-type mice (J:131994)

increased susceptibility to parasitic infection ( J:60609 )

• increase in S. mansoni infection induced liver damage measured by plasma aspartate aminotransferase levels compared to wild-type mice

• marked distension and inflammation of the ileum in S. mansoni infected mice and impaired parasite egg excretion compared to wild-type mice

increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• increased mortality following acute infection with Schistosoma mansoni compared to wild-type mice

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:124116 )

• delayed lobuloalveolar development

• development improves over gestation

integument

abnormal mammary gland growth during pregnancy ( J:124116 )

• delayed lobuloalveolar development

• development improves over gestation

reproductive system

abnormal mammary gland growth during pregnancy ( J:124116 )

• delayed lobuloalveolar development

• development improves over gestation

digestive/alimentary system

ileum inflammation ( J:60609 )

• marked distension and inflammation of the ileum in S. mansoni infected mice

• circulating levels of LPS in S. mansoni infected mice are elevated indicating impaired integrity of the gut

• T cells in the intestine have a Th1 like phenotype in S. mansoni infected mice rather than the Th2 like phenotype seen in wild-type mice

hematopoietic system

decreased IgG1 level ( J:178986 )

• in an anti-NP response

abnormal splenocyte physiology ( J:60609 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• increased mortality following chronic infection with Schistosoma mansoni compared to wild-type mice

immune system

increased eosinophil cell number ( J:113543 )

• eosinophilia is delayed compared to wild-type, but correlates with worm expulsion after induction

abnormal immune system physiology ( J:89095 )

• homozygotes are otherwise healthy and fertile

decreased IgE level ( J:72587 , J:113543 )

• in Leishmania mexicana infected mice compared to wild-type mice (J:72587)

• mutants fail to produce IgE, due to deletion of Il4 (J:113543)

decreased IgG level ( J:89095 )

• IgG1 response to immunization with the protein antigen OVA is severely impaired

decreased IgG1 level ( J:72587 )

• in Leishmania mexicana infected mice compared to wild-type mice

abnormal T-helper 2 physiology ( J:89095 )

• homozygotes do not develop pulmonary granuloma formation in response to schistosome egg immunization

• eosinophil infiltration is absent in response to schistosome egg immunization

• impaired responses are greater than those seen in Il4^tm1Cgn and Il13^tm2Anjm homozygotes

abnormal splenocyte physiology ( J:72587 )

• Leishmania mexicana antigen stimulated cells from L. mexicana infected mice produce increased amounts of IL12 and IFNG

granulomatous inflammation ( J:113543 )

• primary granuloma formation and volumes in lungs after Scistosoma infection are severely reduced (<10%) compared to wild-type

• secondary granuloma formation is reduced vs wild-type after second exposure to parasite eggs

abnormal susceptibility to infection ( J:113543 )

• expulsion of worms from intestines (50% by day 25) is delayed compared to wild-type

decreased susceptibility to parasitic infection ( J:72587 )

• highly resistant to development of Leishmania mexicana induced skin lesions

• at 12 weeks after Leishmania mexicana infection the number of parasites is reduced compared to wild-type mice

increased susceptibility to parasitic infection ( J:89095 , J:113543 )

• the expulsion of parasitic worms from the gut is delayed (J:89095)

• this delay is longer than that seen in Il13^tm2Anjm homozygotes (J:89095)

• after N. brasiliensis (nematode) infection, expulsion of worms from intestines is delayed with ~50% of worms remaining in intestine after 25 days, whereas wild-type mice expel all worms within 5-10 days (J:113543)

increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• increased mortality following chronic infection with Schistosoma mansoni compared to wild-type mice

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:113543 )

• in response to infection, a delayed increase in goblet cell numbers is seen up to 20 days post-infection, but by 30 days, numbers are equivalent to those found in wild-type at 10 days

hematopoietic system

increased eosinophil cell number ( J:113543 )

• eosinophilia is delayed compared to wild-type, but correlates with worm expulsion after induction

decreased IgE level ( J:72587 , J:113543 )

• in Leishmania mexicana infected mice compared to wild-type mice (J:72587)

• mutants fail to produce IgE, due to deletion of Il4 (J:113543)

decreased IgG level ( J:89095 )

• IgG1 response to immunization with the protein antigen OVA is severely impaired

decreased IgG1 level ( J:72587 )

• in Leishmania mexicana infected mice compared to wild-type mice

abnormal T-helper 2 physiology ( J:89095 )

• homozygotes do not develop pulmonary granuloma formation in response to schistosome egg immunization

• eosinophil infiltration is absent in response to schistosome egg immunization

• impaired responses are greater than those seen in Il4^tm1Cgn and Il13^tm2Anjm homozygotes

abnormal splenocyte physiology ( J:72587 )

• Leishmania mexicana antigen stimulated cells from L. mexicana infected mice produce increased amounts of IL12 and IFNG

cellular

abnormal intestinal goblet cell morphology ( J:113543 )

• in response to infection, a delayed increase in goblet cell numbers is seen up to 20 days post-infection, but by 30 days, numbers are equivalent to those found in wild-type at 10 days

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