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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Tbx1-cre)1Joe
transgene insertion 1, Jonathan A Epstein
MGI:3037834
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Chd7Gt(XK403)Byg/Chd7+
Tg(Tbx1-cre)1Joe/0
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) MGI:4410360
cn2
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tbx1-cre)1Joe/0
Not Specified MGI:3037863


Genotype
MGI:4410360
cn1
Allelic
Composition
Chd7Gt(XK403)Byg/Chd7+
Tg(Tbx1-cre)1Joe/0
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7Gt(XK403)Byg mutation (0 available); any Chd7 mutation (71 available)
Tg(Tbx1-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3037863
cn2
Allelic
Composition
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tbx1-cre)1Joe/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (10 available)
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (10 available)
Tg(Tbx1-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die between E18.5 and P1

cardiovascular system
N
• some defects observed as a result of Tbx1-deficiency, including those involving the aortic arch, were not observed
• exhibit variable cardiovascular patterning defects listed below
• duplication of the internal carotid arteries
• impaired differentiation in the great vessels
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle
• Tetrology of Fallot
• atrial septal defects
• ventricular septal defects

immune system
• some exhibit a single lobed thymus

muscle
• impaired differentiation in the great vessels
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle

hematopoietic system
• some exhibit a single lobed thymus

endocrine/exocrine glands
• some exhibit a single lobed thymus

Mouse Models of Human Disease
OMIM ID Ref(s)
DiGeorge Syndrome; DGS 188400 J:88814





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory