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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Tbx1-cre)1Joe
transgene insertion 1, Jonathan A Epstein
MGI:3037834
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Chd7Gt(XK403)Byg/Chd7+
Tg(Tbx1-cre)1Joe/0
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) MGI:4410360
cn2
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tbx1-cre)1Joe/0
Not Specified MGI:3037863


Genotype
MGI:4410360
cn1
Allelic
Composition
Chd7Gt(XK403)Byg/Chd7+
Tg(Tbx1-cre)1Joe/0
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7Gt(XK403)Byg mutation (0 available); any Chd7 mutation (42 available)
Tg(Tbx1-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in all mice (J:154590)
• in all mice (J:154590)
• in 17% of mice (J:154590)
• in 17% of mice (J:154590)

craniofacial
• in all mice (J:154590)
• in all mice (J:154590)
• in 17% of mice (J:154590)
• in 17% of mice (J:154590)

embryogenesis
• in all mice (J:154590)
• in all mice (J:154590)
• in 17% of mice (J:154590)
• in 17% of mice (J:154590)




Genotype
MGI:3037863
cn2
Allelic
Composition
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Tbx1-cre)1Joe/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (8 available)
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (8 available)
Tg(Tbx1-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die between E18.5 and P1 (J:88814)
• most mice die between E18.5 and P1 (J:88814)

cardiovascular system
N
• some defects observed as a result of Tbx1-deficiency, including those involving the aortic arch, were not observed (J:88814)
• some defects observed as a result of Tbx1-deficiency, including those involving the aortic arch, were not observed (J:88814)
• exhibit variable cardiovascular patterning defects listed below (J:88814)
• exhibit variable cardiovascular patterning defects listed below (J:88814)
• duplication of the internal carotid arteries (J:88814)
• duplication of the internal carotid arteries (J:88814)
• impaired differentiation in the great vessels (J:88814)
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle (J:88814)
• impaired differentiation in the great vessels (J:88814)
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle (J:88814)
• Tetrology of Fallot (J:88814)
• Tetrology of Fallot (J:88814)
• atrial septal defects (J:88814)
• atrial septal defects (J:88814)
• ventricular septal defects (J:88814)
• ventricular septal defects (J:88814)

immune system
• some exhibit a single lobed thymus (J:88814)
• some exhibit a single lobed thymus (J:88814)

muscle
• impaired differentiation in the great vessels (J:88814)
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle (J:88814)
• impaired differentiation in the great vessels (J:88814)
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle (J:88814)

hematopoietic system
• some exhibit a single lobed thymus (J:88814)
• some exhibit a single lobed thymus (J:88814)

endocrine/exocrine glands
• some exhibit a single lobed thymus (J:88814)
• some exhibit a single lobed thymus (J:88814)

Mouse Models of Human Disease
OMIM ID Ref(s)
DiGeorge Syndrome; DGS 188400 J:88814





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory