Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7Gt(XK403)Byg mutation
(0 available);
any
Chd7 mutation
(136 available)
Tg(Tbx1-cre)1Joe mutation
(0 available)
|
|
|
Effects of Cre-mediated rescue of Chd7Gt(XK403)Byg mutation on the arch artery phenotype at E10.5
cardiovascular system
craniofacial
embryo
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation
(1 available);
any
Fgf8 mutation
(18 available)
Fgf8tm1.4Mrt mutation
(0 available);
any
Fgf8 mutation
(18 available)
Tg(Tbx1-cre)1Joe mutation
(0 available)
|
|
|
mortality/aging
|
• most mice die between E18.5 and P1
|
cardiovascular system
N |
• some defects observed as a result of Tbx1-deficiency, including those involving the aortic arch, were not observed
|
|
• exhibit variable cardiovascular patterning defects listed below
|
|
• duplication of the internal carotid arteries
|
|
• impaired differentiation in the great vessels
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle
|
|
• ventricular septal defects
|
immune system
|
• some exhibit a single lobed thymus
|
muscle
|
• impaired differentiation in the great vessels
• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle
|
hematopoietic system
|
• some exhibit a single lobed thymus
|
endocrine/exocrine glands
|
• some exhibit a single lobed thymus
|