mortality/aging

• most mice die between E18.5 and P1

cardiovascular system

cardiovascular system phenotype ( J:88814 )

N	• some defects observed as a result of Tbx1-deficiency, including those involving the aortic arch, were not observed (J:88814)

• exhibit variable cardiovascular patterning defects listed below

aortic dissection ( J:88814 )

abnormal carotid artery morphology ( J:88814 )

• duplication of the internal carotid arteries

• impaired differentiation in the great vessels

• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle

abnormal heart development ( J:88814 )

• Tetrology of Fallot

persistent truncus arteriosis ( J:88814 )

double outlet right ventricle ( J:88814 )

transposition of great arteries ( J:88814 )

atrial septal defect ( J:88814 )

• atrial septal defects

• ventricular septal defects

immune system

abnormal thymus morphology ( J:88814 )

• some exhibit a single lobed thymus

small thymus ( J:88814 )

muscle

• impaired differentiation in the great vessels

• muscular wall is of variable thickness and lacks the striated structural appearance of normal arterial smooth muscle

hematopoietic system

abnormal thymus morphology ( J:88814 )

• some exhibit a single lobed thymus

small thymus ( J:88814 )

Mouse Models of Human Disease		OMIM ID	Ref(s)
DiGeorge Syndrome; DGS		188400	J:88814