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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Btlatm1Kmm
targeted mutation 1, Kenneth M Murphy
MGI:3027713
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Btlatm1Kmm/Btlatm1Kmm B6.129S-Btlatm1Kmm MGI:3706172
hm2
 		Btlatm1Kmm/Btlatm1Kmm involves: 129S/SvEv MGI:3027779
cx3
 		Btlatm1Kmm/Btlatm1Kmm
Pdcd1tm1Hon/Pdcd1tm1Hon 		B6.129S-Pdcd1tm1Hon Btlatm1Kmm MGI:3706173
cx4
 		Btlatm1Kmm/Btlatm1Kmm
Tg(DO11.10)10Dlo/? 		involves: 129S/SvEv * BALB/c * C3H * C57BL/6 MGI:3841449


Genotype
MGI:3706172
hm1
Allelic
Composition		 Btlatm1Kmm/Btlatm1Kmm
Genetic
Background		 B6.129S-Btlatm1Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btlatm1Kmm mutation (3 available); any Btla mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:119356 )
• splenocytes in mice receiving a Bm12 to B6 allograft show significantly higher anti-donor responder frequencies when challenged with Bm12 antigen presenting cells
decreased T cell proliferation ( J:119356 )
• marginal decrease in proliferation of CD8+ T cells, and no decrease in CD4+ T cells, stimulated with fully MHC mismatched cells
increased T cell proliferation ( J:119356 )
• increased proliferation of CD4+ T cells stimulated with MHC class II antigens
• splenocytes adoptively transfered into irradiated Bm12 hosts enter the cell cycle and undergo multiple rounds of division within 72 hours, unlike wild-type cells
• CD8+ T cells show a marginal increase in proliferation in response to MHC class II antigens
• however, cells receiving strong alloreactive stimulation show little difference from wild-type cells
decreased interferon-gamma secretion ( J:119356 )
• reduced production of IFNG by alloreactive T cells in response to strong alloactivation (full MHC mismatch)
decreased interleukin-2 secretion ( J:119356 )
• reduced production of IL2 by alloreactive T cells in response to strong alloactivation (full MHC mismatch)
increased length of allograft survival ( J:119356 )
• increases survival of fully MHC-mismatched cardiac allografts (12 +/- 5 days) compared to wild-type (8 +/- 1 days)
• treatment with rapamycin significantly prolongs allograft survival (53 +/- 12 days) compared to treated wild-type (11 +/- 2 days)

hematopoietic system
abnormal T cell activation ( J:119356 )
• splenocytes in mice receiving a Bm12 to B6 allograft show significantly higher anti-donor responder frequencies when challenged with Bm12 antigen presenting cells
decreased T cell proliferation ( J:119356 )
• marginal decrease in proliferation of CD8+ T cells, and no decrease in CD4+ T cells, stimulated with fully MHC mismatched cells
increased T cell proliferation ( J:119356 )
• increased proliferation of CD4+ T cells stimulated with MHC class II antigens
• splenocytes adoptively transfered into irradiated Bm12 hosts enter the cell cycle and undergo multiple rounds of division within 72 hours, unlike wild-type cells
• CD8+ T cells show a marginal increase in proliferation in response to MHC class II antigens
• however, cells receiving strong alloreactive stimulation show little difference from wild-type cells

cellular
decreased T cell proliferation ( J:119356 )
• marginal decrease in proliferation of CD8+ T cells, and no decrease in CD4+ T cells, stimulated with fully MHC mismatched cells
increased T cell proliferation ( J:119356 )
• increased proliferation of CD4+ T cells stimulated with MHC class II antigens
• splenocytes adoptively transfered into irradiated Bm12 hosts enter the cell cycle and undergo multiple rounds of division within 72 hours, unlike wild-type cells
• CD8+ T cells show a marginal increase in proliferation in response to MHC class II antigens
• however, cells receiving strong alloreactive stimulation show little difference from wild-type cells




Genotype
MGI:3027779
hm2
Allelic
Composition		 Btlatm1Kmm/Btlatm1Kmm
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btlatm1Kmm mutation (3 available); any Btla mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell proliferation ( J:84084 )
• B cells show a slightly greater proliferative response to stimulation with anti-IgM
increased T cell proliferation ( J:84084 )
• T cells show a heightened proliferative response to stimulation with anti-CD3 antibody
abnormal humoral immune response ( J:84084 )
• 4 weeks after immunization with nitrophenol-conjugated keyhole limpet hemocyanin (NP-KLH), mice show a 3-fold increase in the levels of NP-KLH specific IgG1, IgG2a and IgG2b
increased IgG1 level ( J:84084 )
• 3-fold increase compared to wild-type in response to NP-KLH immunization
increased IgG2a level ( J:84084 )
• 3-fold increase compared to wild-type in response to NP-KLH immunization
increased IgG2b level ( J:84084 )
• 3-fold increase compared to wild-type in response to NP-KLH immunization
increased susceptibility to experimental autoimmune encephalomyelitis ( J:84084 )
• mutants show increased clinical score, earlier onset, and prolonged duration of experimentally induced autoimmune encephalomyelitis compared to wild-type

hematopoietic system
increased B cell proliferation ( J:84084 )
• B cells show a slightly greater proliferative response to stimulation with anti-IgM
increased T cell proliferation ( J:84084 )
• T cells show a heightened proliferative response to stimulation with anti-CD3 antibody
increased IgG1 level ( J:84084 )
• 3-fold increase compared to wild-type in response to NP-KLH immunization
increased IgG2a level ( J:84084 )
• 3-fold increase compared to wild-type in response to NP-KLH immunization
increased IgG2b level ( J:84084 )
• 3-fold increase compared to wild-type in response to NP-KLH immunization

cellular
increased B cell proliferation ( J:84084 )
• B cells show a slightly greater proliferative response to stimulation with anti-IgM
increased T cell proliferation ( J:84084 )
• T cells show a heightened proliferative response to stimulation with anti-CD3 antibody




Genotype
MGI:3706173
cx3
Allelic
Composition		 Btlatm1Kmm/Btlatm1Kmm
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background		 B6.129S-Pdcd1tm1Hon Btlatm1Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btlatm1Kmm mutation (3 available); any Btla mutation (30 available)
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:119356 )
• increase in proliferation in response to fully MHC-mismatched stimulation
• increase is decreased by rapamycin treatment
decreased length of allograft survival ( J:119356 )
• decreased survival time of cardiac allografts (source strain Bm12; 10.5 +/- 1.5 days) compared to mice homozygous for the Btla allele alone (14.3 +/- 3.8 days) or wild-type mice (over 100 days)

hematopoietic system
increased T cell proliferation ( J:119356 )
• increase in proliferation in response to fully MHC-mismatched stimulation
• increase is decreased by rapamycin treatment

cellular
increased T cell proliferation ( J:119356 )
• increase in proliferation in response to fully MHC-mismatched stimulation
• increase is decreased by rapamycin treatment




Genotype
MGI:3841449
cx4
Allelic
Composition		 Btlatm1Kmm/Btlatm1Kmm
Tg(DO11.10)10Dlo/?
Genetic
Background		 involves: 129S/SvEv * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btlatm1Kmm mutation (3 available); any Btla mutation (30 available)
Tg(DO11.10)10Dlo mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T cell proliferation ( J:84084 )
• fully polarized TH1 cells show a 2-fold increase in proliferation in response to OVA peptide presented by either CD8+ or CD8-CD11c+ DCs

immune system
increased T cell proliferation ( J:84084 )
• fully polarized TH1 cells show a 2-fold increase in proliferation in response to OVA peptide presented by either CD8+ or CD8-CD11c+ DCs

cellular
increased T cell proliferation ( J:84084 )
• fully polarized TH1 cells show a 2-fold increase in proliferation in response to OVA peptide presented by either CD8+ or CD8-CD11c+ DCs




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory