About   Help   FAQ
Targeted Allele Detail
Symbol: Btlatm1Kmm
Name: B and T lymphocyte associated; targeted mutation 1, Kenneth M Murphy
MGI ID: MGI:3027713
Synonyms: BTLA-
Gene: Btla  Location: Chr16:45043121-45073258 bp, + strand  Genetic Position: Chr16, 29.52 cM
Alliance: Btlatm1Kmm page
Germline Transmission:  Earliest citation of germline transmission: J:84084
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic region containing exons 3, 4 and 5 was replaced with a neomycin selection cassette through homologous recombination. Northern blot analysis on splenocytes derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:84084)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Btla Mutation:  21 strains or lines available
Original:  J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory