All Phenotypes Ift172<wim> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ift172^wim
wimple
MGI:2682066

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ift172^wim/Ift172^wim	C3.B6J-Ift172^wim	MGI:3027423
hm2	Ift172^wim/Ift172^wim	involves: C3HeB/FeJ * C57BL/6J	MGI:3580672
hm3	Ift172^wim/Ift172^wim	involves: C57BL/6J	MGI:4359243
ht4	Ift172^avc1/Ift172^wim	involves: C57BL/6J	MGI:5290082
cx5	Ift172^wim/Del(5D5Mit73-D5Mit351)5Jcs	involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J	MGI:3027424
cx6	Ift172^wim/Ift172^wim Smo^bnb/Smo^bnb	involves: C57BL/6J	MGI:3624270
cx7	Ift172^wim/Ift172^wim Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?	involves: C57BL/6J * FVB/N	MGI:4355991

Allelic Composition	Ift172^wim/Ift172^wim
Genetic Background	C3.B6J-Ift172^wim

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86437 )

• development is arrested at E10.5-E11.5

cardiovascular system

abnormal direction of heart looping ( J:86437 )

• polarity of heart looping reversed in approximately 40% of E9.5 embryos

embryo

absent embryonic cilia ( J:86437 )

• node cells lack cilia

abnormal floor plate morphology ( J:86437 )

• lack the ventral midline groove in the neural plate

• markers of V3 interneurons and motorneurons were not expressed

open neural tube ( J:86437 )

nervous system

abnormal floor plate morphology ( J:86437 )

• lack the ventral midline groove in the neural plate

• markers of V3 interneurons and motorneurons were not expressed

open neural tube ( J:86437 )

cellular

absent embryonic cilia ( J:86437 )

• node cells lack cilia

Allelic Composition	Ift172^wim/Ift172^wim
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

• die at E10-E11

embryo

abnormal left-right axis patterning ( J:98216 )

• left-right randomization

nervous system

exencephaly ( J:98216 )

abnormal spinal cord morphology ( J:98216 )

• dorsalized spinal cord

Allelic Composition	Ift172^wim/Ift172^wim
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cilium morphology ( J:138139 )

• mouse embryonic fibroblasts do not generate cilia unlike wild-type cells

Allelic Composition	Ift172^avc1/Ift172^wim
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172^avc1 mutation (0 available); any Ift172 mutation (75 available)
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal motile primary cilium morphology ( J:175371 )

• severely decreased mean ventral node cilia length at E7.5

cellular

abnormal cilium morphology ( J:175371 )

• decrease in the percentage of MEFs with cilia compared to wild-type MEFs

• severely decreased cilia length on MEFs with a large population of truncated cilia and a much smaller population of full length cilia

abnormal motile primary cilium morphology ( J:175371 )

• severely decreased mean ventral node cilia length at E7.5

cardiovascular system

abnormal cardiovascular system morphology ( J:175371 )

• cardiac abnormalities

craniofacial

abnormal craniofacial morphology ( J:175371 )

• craniofacial abnormalities

limbs/digits/tail

abnormal limb morphology ( J:175371 )

• limb abnormalities

Allelic Composition	Ift172^wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background	involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available); any Del(5D5Mit73-D5Mit351)5Jcs mutation (0 available)
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal floor plate morphology ( J:86437 )

• lack the ventral midline groove in the neural plate

• markers of V3 interneurons and motor neurons were not expressed

embryo

abnormal floor plate morphology ( J:86437 )

• lack the ventral midline groove in the neural plate

• markers of V3 interneurons and motor neurons were not expressed

Allelic Composition	Ift172^wim/Ift172^wim Smo^bnb/Smo^bnb
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)
Smo^bnb mutation (0 available); any Smo mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:100466 )

• double mutants survive to E10.5-11.5

cardiovascular system

abnormal direction of heart looping ( J:100466 )

• mutants exhibit randomization of heart looping polarity

nervous system

open neural tube ( J:100466 )

• double mutants have an open neural tube at E10.5

decreased motor neuron number ( J:100466 )

• only a few motor neurons are detected in the spinal cords of mutants

embryo

open neural tube ( J:100466 )

• double mutants have an open neural tube at E10.5

Allelic Composition	Ift172^wim/Ift172^wim Kif7^maki/Kif7^maki Tg(Hlxb9-GFP)1Tmj/?
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172^wim mutation (0 available); any Ift172 mutation (75 available)
Kif7^maki mutation (0 available); any Kif7 mutation (39 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:151965 )

• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube

absent floor plate ( J:151965 )

embryo

abnormal neural tube morphology ( J:151965 )

• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube

absent floor plate ( J:151965 )

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