Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation
(0 available);
any
Map3k1 mutation
(62 available)
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hearing/vestibular/ear
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• at 2 weeks
• however, mice exhibit normal outer hair cell proliferation
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• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks
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• very severe in small patches
• inner hair cells, outer hair cells and pillar cells are replaced with rosette-like formation composed of Claudius and Hensen cells at 9 weeks
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• at 2, 4 and 9 weeks of age
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nervous system
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• at 2 weeks
• however, mice exhibit normal outer hair cell proliferation
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• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation
(0 available);
any
Map3k1 mutation
(62 available)
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vision/eye
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• the number of apoptotic cells is increased in the retina at P14-P21
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• iris overgrowth
• however, Meibomian glands are normal
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• stromal neovascularization and thickening of the cornea
• corneas show macrophage invasion in the stroma
• surgical suture of the eyelid partially restores normal corneal appearance and reduces macrophage invasion
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• stromal thickening
• surgical suture of the eyelid partially restores normal corneal appearance and reduces corneal thickening
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• cloudiness of the cornea
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• retinas start to show misallocated cell bodies at the posterior side at P7 and develop sporadic rosette structures posterior to the photoreceptor layers at P15
• retina shows invasion of macrophages at 1 year of age
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• localized neo-vascularization in RPE and outer nuclear layer
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• an increase in late-born Muller glial cells is seen in retinas
• Muller glial processes protrude beyond the boundary of the outer limiting membrane and displace the rod photoreceptors in hyperplastic lesions
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• mice show broken down retinal pigment epithelium (RPE) resulting in focal RPE leak
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• the number of mitotic progenitors is slightly increased at P6 and significantly higher at P7 and P8 at the outer edge of the retina and some mitotic progenitors are located in unusual positions in the inner segment of the retinas
• S-phase+ cells are more abundant at P6-P10 in the retina, especially in peripheral regions
• however, mitosis ceases at P12 in the retina as in controls
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• regional dislocalization in the outer nuclear layer and rosette-like arrangements in this layer
• mice with opened eyelids sutured closed right after birth and suture removed at P14 when eyelids open normally show rosette structure in the outer nuclear layer at P15
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• thinner outer nuclear layer at 1 year of age
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• signs of retinal degeneration are seen at 1 year of age
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• some Muller glia nuclei undergo mitosis and migrate out of the inner nuclear layer, indicating proliferative gliosis
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cardiovascular system
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• localized neo-vascularization in RPE and outer nuclear layer
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cellular
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• the number of apoptotic cells is increased in the retina at P14-P21
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nervous system
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• an increase in late-born Muller glial cells is seen in retinas
• Muller glial processes protrude beyond the boundary of the outer limiting membrane and displace the rod photoreceptors in hyperplastic lesions
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pigmentation
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• mice show broken down retinal pigment epithelium (RPE) resulting in focal RPE leak
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation
(0 available);
any
Map3k1 mutation
(62 available)
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vision/eye
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• at E15.5, the eyelid tip epithelium is thinner than normal; however, number of cell layers is normal
• at E15.5, the mutant eyelid epithelium displays tight cell-cell contacts with signifcantly fewer and smaller intercellular spaces, unlike in wild-type controls
• no abnormal eyelid morphology is noted at E14.5
• by E16, the mutant eyelid fails to move forward, leaving the ocular surface
exposed
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• impaired eyelid closure is noted at E16
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• at E15.5, no clumps of round cells are detected along the mutant eyelid margin, unlike in wild-type controls
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• all homozygotes exhibit eyelids open at birth
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integument
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• keratinocytes ineffective in wound closure
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Allelic
Composition |
Map3k1tm1Yxia/Map3k1+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation
(0 available);
any
Map3k1 mutation
(62 available)
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hearing/vestibular/ear
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• however, mice do not exhibit outer hair cell degeneration
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nervous system
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• however, mice do not exhibit outer hair cell degeneration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1goya mutation
(0 available);
any
Map3k1 mutation
(62 available)
Map3k1tm1Yxia mutation
(0 available);
any
Map3k1 mutation
(62 available)
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hearing/vestibular/ear
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• at 9 weeks of age with an apical-to-basal gradient
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation
(0 available);
any
Map3k1 mutation
(62 available)
Mapk8tm1Wag mutation
(1 available);
any
Mapk8 mutation
(71 available)
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vision/eye
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• eyes are open at birth
• however, mice exhibit normal retinal morphology
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vision/eye
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• eyes are open at birth
• however, mice exhibit normal retinal morphology
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Analysis Tools