Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tg(GFAP-TVA)5Hev mutation
(1 available)
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mortality/aging
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• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 30% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice
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neoplasm
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• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
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• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found
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nervous system
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• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
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• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm2.1Rdp mutation
(2 available);
any
Cdkn2a mutation
(62 available)
Tg(GFAP-TVA)5Hev mutation
(1 available)
|
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mortality/aging
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• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 25% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice
|
neoplasm
|
• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
|
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• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)
|
nervous system
|
• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
|
|
• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tg(GFAP-TVA)5Hev mutation
(1 available)
|
|
|
mortality/aging
|
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 25% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice
|
neoplasm
|
• 20 gliomas are discovered in 26 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
|
|
• 3 grade II (similar to human oligodendroglioma) and 17 grade III (similar to anaplastic oligodendroglioma)
|
nervous system
|
• 20 gliomas are discovered in 26 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
|
|
• 3 grade II (similar to human oligodendroglioma) and 17 grade III (similar to anaplastic oligodendroglioma)
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Allelic Composition |
Tg(GFAP-TVA)5Hev/0
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Genetic Background |
involves: BALB/c * C57BL/6 * FVB/N |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-TVA)5Hev mutation
(1 available)
|
|
|
nervous system
|
• 5 gliomas are discovered in 31 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
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• 5 grade II (similar to human oligodendroglioma)
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• in mice transfected with replication-competent ALV splice acceptor viral vector expressing bFGF glial cells exhibit increased proliferation and migration compared to similarly treated wild-type cells
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neoplasm
|
• 5 gliomas are discovered in 31 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
|
|
• 5 grade II (similar to human oligodendroglioma)
|