Tg(GFAP-TVA)5Hev
Transgene Detail

Summary

• Symbol: Tg(GFAP-TVA)5Hev
• Name: transgene insertion 5, Harold E Varmus
• MGI ID: MGI:2663943
• Synonyms: Gtv-a
• Transgene: Tg(GFAP-TVA)5Hev Location: unknown
• Alliance: Tg(GFAP-TVA)5Hev page

Transgene origin

• Strain of Origin: mixed

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene consists of the astrocyte-specific human glial fibrillary acidic protein (GFAP) promoter, TVA gene (avian cell surface receptor), and a portion of the mouse protamine (Prm1) gene which supplies intronic sequence and a polyadenylation site. The transgene expresses the quail TVA for subgroup A avian leukosis viruses. (J:69971)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-TVA)5Hev

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The construct was injected into embryos generated by crossing an FVB/N mouse to a (C57BL/6 x BALB/c)F1 mouse. Glial cells in transgenic mice are specifically susceptible to infection by replication-competent ALV splice acceptor (RCAS) retroviral vectors.

References

• Original: J:69971 Holland EC, et al., Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1218-23
• All: 31 reference(s)