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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Plp1-cre/ERT2)1Ueli
transgene insertion 1, Ueli Suter
MGI:2663093
Summary 6 genotypes


Genotype
MGI:7331503
cn1
Allelic
Composition		 Cmtm5tm1c(KOMP)Wtsi/Cmtm5tm1c(KOMP)Wtsi
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 B6.Cg-Cmtm5tm1c(KOMP)Wtsi Tg(Plp1-cre/ERT2)1Ueli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmtm5tm1c(KOMP)Wtsi mutation (0 available); any Cmtm5 mutation (17 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:327261 )
• adults show pathological appearing axons in optic nerves (axonopathy) 4 months after tamoxifen injection




Genotype
MGI:5902377
cn2
Allelic
Composition		 Septin8tm1c(EUCOMM)Wtsi/Septin8tm1c(EUCOMM)Wtsi
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 B6N.Cg-Septin8tm1c(EUCOMM)Wtsi Tg(Plp1-cre/ERT2)1Ueli
Cell Lines EPD0060_3_G04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin8tm1c(EUCOMM)Wtsi mutation (0 available); any Septin8 mutation (31 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
tomacula ( J:236408 )
• in tamoxifen-treated mice
demyelination ( J:236408 )
• tamoxifen-treated mice exhibit reduction in the spetin scaffold in mature myelin compared with control mice




Genotype
MGI:4837112
cn3
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain white matter morphology ( J:161841 )
• mice treated with tamoxifen to induce cre-recombination exhibit an increase in white matter volume
abnormal corpus callosum morphology ( J:161841 )
• many axons in the corpus callosum are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination
abnormal myelin sheath morphology ( J:161841 )
• increase in myelin sheath thickness
• outfoldings of the myelin sheaths in CNS and PNS are observed
abnormal optic nerve morphology ( J:161841 )
• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination
hypermyelination ( J:161841 )
• many axons in the corpus callosum and optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination
• normally nonmyelinated C-fiber axons are spirally enwrapped by Remak Schwann cells are seen in mice treated with tamoxifen to induce cre-recombination

vision/eye
abnormal optic nerve morphology ( J:161841 )
• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination




Genotype
MGI:6511252
cn4
Allelic
Composition		 Cmtm6tm1c(EUCOMM)Wtsi/Cmtm6tm1c(EUCOMM)Wtsi
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmtm6tm1c(EUCOMM)Wtsi mutation (0 available); any Cmtm6 mutation (13 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:296495 )
• increased diameter of sciatic nerve axons 2 and 6 months after treatment with tamoxifen at age 2 months




Genotype
MGI:5460891
cn5
Allelic
Composition		 Cdc42tm1Brak/Cdc42tm1Brak
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Brak mutation (0 available); any Cdc42 mutation (43 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelin sheath morphology ( J:190437 )
• mutants injected with tamoxifen at 10 weeks of age exhibit prominent myelin foldings in sciatic nerves




Genotype
MGI:5460888
cn6
Allelic
Composition		 Fgd4tm1Ics/Fgd4tm1Ics
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgd4tm1Ics mutation (0 available); any Fgd4 mutation (82 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelin sheath morphology ( J:190437 )
• mutants injected with tamoxifen exhibit aberrant myelin in peripheral nerves at 30 weeks of age




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory