• mutant adrenal glands are hypoplastic ad display a severe loss at the level of the glucocorticoid-producing fasciculata layer

• homozygotes exhibit only a few remaining POMC (ACTH)-positive pituitary cells relative to wild-type and heterozygous control mice

• after a 24-hr fast, homozygotes display a significantly greater fasting-induced hypoglycemia than wild-type and heterozygous control mice

• fasting-induced hypoglycemia can be associated with seizures or death during fasting

• homozygotes exhibit significantly higher basal plasma glucose levels relative to wild-type or heterozygous control mice

• unlike wild-type and heterozygous control mice, homozygotes exhibit no detectable plasma corticosterone levels

• homozygotes display very low, though still detectable, plasma ACTH levels, relative to wild-type and heterozygous control mice

• homozygotes display increased water retention in their fur

• homozygotes exhibit only a few remaining POMC (ACTH)-positive pituitary cells relative to wild-type and heterozygous control mice

• homozygotes show a yellow ventrum pigmentation instead of the light gray pigmentation observed in wild-type or heterozygous control mice

• homozygotes display deficient pigmentation

• homozygotes are fertile, indicating a functional pituitary gonadal axis (J:82651)

• homozygotes show a yellow ventrum pigmentation instead of the light gray pigmentation observed in wild-type or heterozygous control mice