• increased apoptosis 1 week after treatment with adriamycin

• increased foot process effacement 1 day after treatment with adriamycin

• smaller glomeruli and glomerular tuft area

• increased mesangial matrix accumulation

• mesangial expansion 1 day after treatment with adriamycin

• focal mesangiolysis and lesions 1 day after treatment with adriamycin

• increased succeptibility to adriamycin induced kidney damage

• increased glomerular matrix deposition and hyalinosis by 1 week after treatment with adriamycin

• serious interstitial damage and increased apoptosis 1 week after treatment with adriamycin

• abnormally increased creatinine levels as a result of adriamycin treatment

• abnormally increased albuminuria as a result of treatment with adriamycin

• increased susceptibility to glomerulopathy in response to adriamycin-induced kidney injury

• increased apoptosis 1 week after treatment with adriamycin

• decreased accumulation of myofibroblasts in kidneys of 7 week old mice compared to mice only homozygous for the collagen deficiency

• infiltration of the kidney tubular interstitium by macrophage is less in 4 week old mice than in mice only homozygous for the collagen deficiency

• attenuated damage to the glomerular basement membrane although damage still present

• slower rate of renal disease progression

• end stage renal failure delayed to 14.5 weeks rather than 8.5 weeks as in mice only homozygous for the collagen deficiency

• onset of proteinuria is delayed relative to mice only homozygous for the collagen deficiency

• infiltration of the kidney tubular interstitium by macrophage is less in 4 week old mice than in mice only homozygous for the collagen deficiency