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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nrtntm1Jmi
targeted mutation 1, Jeffrey Milbrandt
MGI:2448936
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nrtntm1Jmi/Nrtntm1Jmi involves: 129X1/SvJ * C57BL/6 MGI:3513818
cx2
Gdnftm1Rosl/Gdnf+
Nrtntm1Jmi/Nrtntm1Jmi
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3588574
cx3
Gdnftm1Rosl/Gdnftm1Rosl
Nrtntm1Jmi/Nrtntm1Jmi
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3588573


Genotype
MGI:3513818
hm1
Allelic
Composition
Nrtntm1Jmi/Nrtntm1Jmi
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrtntm1Jmi mutation (1 available); any Nrtn mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• reduced blink reflex due to abnormal corneal sensation

endocrine/exocrine glands
• decreased mucosal thickening and folding in the secretory epithelium of the ventral prostate
• crusting drainage

immune system
• Il-1beta levels significantly increased by 4 months of age
• mice display phenotypic changes and ocular surface inflammation that mimic human keratoconjunctivitis sicca

muscle
• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation
• muscle strips from the gut with reduced spontaneous contractile activity
• contractile strength of stimulated gut muscles considerably reduced

reproductive system
• decreased mucosal thickening and folding in the secretory epithelium of the ventral prostate

vision/eye
• significantly reduced number of globlet cells in the bulbar and tarsal conjunctiva
• leukocytes found in epithelium
• thickened at 10 weeks from 5 layers to 8 with a basal cell phenotype
• eyes set more deeply in sockets
• drooping, thickened eyelids by 2 months of age
• eyelid thickening in most mice by 2 months of age
• permeability of corneal epithelium increased
• crusting drainage
• Il-1beta levels significantly increased by 4 months of age
• mice display phenotypic changes and ocular surface inflammation that mimic human keratoconjunctivitis sicca
• reduced aqueous tear production becoming significant at 8 weeks
• significantly delayed tear fluorescein clearance at >8 weeks

nervous system
• decreased small fiber density in the small intestine and colon (by 40% in duodenum) (J:53261)
• 35% fewer small bowel submucosal neurons, however the number of colonic submucosal neurons and colon and small bowel myenteric neurons is normal (J:82456)
• myenteric neuron size is reduced by 29% in the small bowel and 33% in the colon, however submucosal neuron size is normal (J:82456)
• density of acetylcholinesterase-stained neuronal fibers in the myenteric plexus is reduced by 32% in the small bowel and 22% in the colon (J:82456)
• reduced number of ciliary ganglion neurons but pupil function is normal
• otic ganglion cell size reduced but numbers of cells is normal
• severe reduction or lack of innervation to the lacrimal gland (J:53261)
• submandibular gland neurons smaller and fibers thinner (J:53261)
• parasympathetic innervation of glandular tissue in reproductive organs lost (J:89350)
• nerve fibers are almost completely absent in the lacrimal gland of adult mice, indicating reduced parasympathetic innervation to the lacrimal gland
• 70-95% reduction in substance P and 35-70% reduction in VIP release

digestive/alimentary system
• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation




Genotype
MGI:3588574
cx2
Allelic
Composition
Gdnftm1Rosl/Gdnf+
Nrtntm1Jmi/Nrtntm1Jmi
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Rosl mutation (0 available); any Gdnf mutation (10 available)
Nrtntm1Jmi mutation (1 available); any Nrtn mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

digestive/alimentary system
• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

nervous system
• decrease in the number and cell size of small bowel and colon myenteric and submucosal neurons
• density of acetylcholinesterase-stained neuronal fibers in the myenteric plexus is reduced to a similar extent as in homozygous Nrtntm1Jmi mice
• 70-95% reduction in substance P and VIP release




Genotype
MGI:3588573
cx3
Allelic
Composition
Gdnftm1Rosl/Gdnftm1Rosl
Nrtntm1Jmi/Nrtntm1Jmi
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Rosl mutation (0 available); any Gdnf mutation (10 available)
Nrtntm1Jmi mutation (1 available); any Nrtn mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• severe intestinal aganglionosis, similar to that seen in single homozygous Gdnftm1Rosl mice





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory