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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79btm2.1Mnz
targeted mutation 2.1, Michel C Nussenzweig
MGI:2447121
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd79btm2.1Mnz/Cd79btm2.1Mnz involves: 129 * C57BL/6 MGI:3813553
hm2
 		Cd79btm2.1Mnz/Cd79btm2.1Mnz involves: 129/Sv * C57BL/6 MGI:3813607
cx3
 		Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm2.1Mnz/Cd79btm2.1Mnz 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3813551
cx4
 		Cd79atm2Cgn/Cd79atm2Cgn
Cd79btm2.1Mnz/Cd79btm2.1Mnz 		involves: 129/Sv * C57BL/6 MGI:3813610


Genotype
MGI:3813553
hm1
Allelic
Composition		 Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm2.1Mnz mutation (0 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:71100 )
• mature B cells numbers are decreased more than 10-fold in these mice

hematopoietic system
decreased mature B cell number ( J:71100 )
• mature B cells numbers are decreased more than 10-fold in these mice




Genotype
MGI:3813607
hm2
Allelic
Composition		 Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm2.1Mnz mutation (0 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased transitional stage B cell number ( J:66840 )
• IgMlowIgD- CD25+ transitional B cells have increased rates of apoptosis
• B cells by largely fail to progress to the IgM+IgD+ CD25- transitional B cell stage
increased pro-B cell number ( J:66840 )
• pro-B cell numbers are increased in the bone marrow
arrested B cell differentiation ( J:66840 )
• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains
decreased mature B cell number ( J:66840 )
• there is a 70-fold reduction in the number of recirculating mature B cells found in the bone marrow
• the number of mature B cells found in the spleen is reduced by about 50-fold
decreased pre-B cell number ( J:66840 )
• mice have a 25% decrease in IgM-B220+CD43-CD25+ pre-Bcells in the bone marrow
abnormal B cell activation ( J:66840 )
• production of antibodies to T cell dependent antigens is impaired

hematopoietic system
decreased transitional stage B cell number ( J:66840 )
• IgMlowIgD- CD25+ transitional B cells have increased rates of apoptosis
• B cells by largely fail to progress to the IgM+IgD+ CD25- transitional B cell stage
increased pro-B cell number ( J:66840 )
• pro-B cell numbers are increased in the bone marrow
arrested B cell differentiation ( J:66840 )
• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains
decreased mature B cell number ( J:66840 )
• there is a 70-fold reduction in the number of recirculating mature B cells found in the bone marrow
• the number of mature B cells found in the spleen is reduced by about 50-fold
decreased pre-B cell number ( J:66840 )
• mice have a 25% decrease in IgM-B220+CD43-CD25+ pre-Bcells in the bone marrow
abnormal B cell activation ( J:66840 )
• production of antibodies to T cell dependent antigens is impaired




Genotype
MGI:3813551
cx3
Allelic
Composition		 Cd79atm1.1Cgn/Cd79atm1.1Cgn
Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1.1Cgn mutation (0 available); any Cd79a mutation (22 available)
Cd79btm2.1Mnz mutation (0 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested B cell differentiation ( J:71100 )
• B cell development is blocked in the pro-B cell stage at the fraction C'(BP-1+HSAbright step
absent mature B cells ( J:71100 )
• B cells are absent from the periphery

hematopoietic system
arrested B cell differentiation ( J:71100 )
• B cell development is blocked in the pro-B cell stage at the fraction C'(BP-1+HSAbright step
absent mature B cells ( J:71100 )
• B cells are absent from the periphery




Genotype
MGI:3813610
cx4
Allelic
Composition		 Cd79atm2Cgn/Cd79atm2Cgn
Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm2Cgn mutation (0 available); any Cd79a mutation (22 available)
Cd79btm2.1Mnz mutation (0 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased transitional stage B cell number ( J:66840 )
• IgMlowIgD- CD25+ transitional B cells have increased rates of apoptosis
• B cells by largely fail to progress to the IgM+IgD+ CD25- transitional B cell stage
arrested B cell differentiation ( J:66840 )
• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains

hematopoietic system
decreased transitional stage B cell number ( J:66840 )
• IgMlowIgD- CD25+ transitional B cells have increased rates of apoptosis
• B cells by largely fail to progress to the IgM+IgD+ CD25- transitional B cell stage
arrested B cell differentiation ( J:66840 )
• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory