Analysis Tools
hematopoietic system
| N |
• double deficient B cells do not show abnormalities is lysophospholipid-induced adhesion
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Allele Symbol Allele Name Allele ID |
Gnaqtm2Soff targeted mutation 2, Stefan Offermanns MGI:2446355 |
| Summary |
11 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• double deficient B cells do not show abnormalities is lysophospholipid-induced adhesion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in response to tamoxifen
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• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
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• in response to ligation of the external carotid artery, mice exhibit a strong reduction in neointima formation compared with control mice
• however, there is no change in the diameter of the common carotid artery
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• in response to ligation of the external carotid artery, mice exhibit a strong reduction in neointima formation compared with control mice
• however, there is no change in the diameter of the common carotid artery
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• decreased in the plasma of tamoxifen-treated mice
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• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 75% die perinatally
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• pups that die perinatally exhibit varying degrees of myocardial hypoplasia
• however, mutants that survive to adulthood, appear normal and are fertile
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• homozygotes surviving to adulthood exhibit no ventricular hypertrophy in response to pressure-overload induced by aortic constriction, indicating a complete lack of a hypertrophic response
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• homozygotes surviving to adulthood exhibit no ventricular hypertrophy in response to pressure-overload induced by aortic constriction, indicating a complete lack of a hypertrophic response
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• anterior-posterior shortening of craniofacial complex is most pronounced in the snout
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• drastically reduced P9 compared to controls
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• drastically reduced P9 compared to controls
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• severe dwarfism by P9
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• internal organs are reduced in size according to general growth retardation of mutants
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• sutures are much wider than in controls
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• doming of cranial vault is observed at P9
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• anterior-posterior shortening of craniofacial complex is most pronounced in the snout
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• sutures are much wider than in controls
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• doming of cranial vault is observed at P9
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• bulging of costochondral junction (rachitic rosary) is observed in ribs
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• severe osteopenia is observed throughout the skeleton
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• all growth plates display rachitic changes
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• barely detectable in bones of paws and caudal vertebrae at P9
• mineralization of ventral ribs is lacking
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• noted in cervical and caudal vertebrae, bones of paws, and all long bones
• epiphyseal ossification of femur and tibia is lacking at P9
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• evidence of bone resorption is observed in mutants at P9
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• proliferation of cells is significantly enhance compared to controls
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• massively growth-retarded
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• significantly increased levels are observed at P9
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• urine calcium level is strongly increased
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• urine calcium level is strongly increased
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• massively growth-retarded
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced at P9 compared to controls
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• levels are increased compared to controls at P9
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• increased relative to controls
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• increased relative to controls at P9
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• increased relative to controls at P9
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced at P9 compared to controls
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• levels are increased compared to controls
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• increased relative to controls at P9
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• increased relative to controls
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• increased relative to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• incisive alveolar bone in distal mandibular region is relatively well-developed
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• lamina obturans is duplicated
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• duplicated in mutants
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• hyoid is not fused to basisphenoid in all cases; body of hyoid has extended ossification center and is fused to lesser hyoid horn and often with superior horn of thyroid similar to Ednrb-knock-in homozygotes
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• maxillary bones are duplicated in mandibular region
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• duplication of palatine bone is observed
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• duplication of jugal bone in mandibular region is observed
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• lamina obturans is duplicated
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• duplicated in mutants
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• hyoid is not fused to basisphenoid in all cases; body of hyoid has extended ossification center and is fused to lesser hyoid horn and often with superior horn of thyroid similar to Ednrb-knock-in homozygotes
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• maxillary bones are duplicated in mandibular region
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• duplication of palatine bone is observed
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• duplication of jugal bone in mandibular region is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• as mutants age, no significant differences in thyroid size or weight is observed relative to wild-type
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• at 6 months of age, histology is altered; follicular structure is disturbed with few normal follicles remaining
• no increase in thyroid gland weight is observed in 6-8 week-old mice treated with TSH (thyroid stimulating hormone) for 1 week, whereas wild-type mice show a 100% increase in thyroid weight; glands in mutants actually decrease in weight due to slight decrease in follicular lumen size
• no increase in thyrocyte number is observed after TSH treatment in contrast to increase seen in wild-type; thryocytes show hypertrophic response to TSH treatment
• after TSH treatment, colloid area is reduced unlike wild-type thyroids
• mutant thyroids show no response to goitrogenic diet, whereas wild-type mice readily develop hyperplastic goiters
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• cells are often enlarged, columnar and have large nuclei at 6 months of age
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• TSH-induced thyroid hormone release is almost entirely abrogated in mutants
• impaired pinocytic uptake of colloid and reduction in pinocytic vesicle formation in thyroid follicular epithelium upon TSH stimulation is observed in mutants versus wild-type
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• after 6 months of age, about half of animals display overt hypothyroidism
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• beginning at 2 months of age, TSH (thyroid stimulating hormone) plasma levels start to rise and are significantly higher than wild-type at 6 months of age
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• at 6 months, mice show low T4 levels compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• age-dependent reduction in survival due to tonic-clonic seizures
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• around 3 months of age, mice show spontaneous epileptic seizures; animals affected and seizure number per animal increase with age
• mutants show reduced latency to seizure onset and tendency to have stronger seizures when treated with kainic acid or PTZ than wild-type; seizure-induced lethality is greatly increased
• blockade of cannabinoid receptors does not result in aggravation of kainic acid-induced seizures in mutants but does in wild-type controls
• treatment of mutants with endocannabinoid reuptake inhibitor causes a significant amelioration of kainic acid induced seizures
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• most seizures are myoclonic
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• some animals exhibit tonic-clonic seizures with age
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• older animals particularly those with symptomatic epilepsy show neuronal degeneration in CA1 region
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• no CCK4-induced (cholecystokinin receptor2 agonist) current is detected in amygdala slices while inward current response in wild-type is unaffected
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• around 3 months of age, mice show spontaneous epileptic seizures; animals affected and seizure number per animal increase with age
• mutants show reduced latency to seizure onset and tendency to have stronger seizures when treated with kainic acid or PTZ than wild-type; seizure-induced lethality is greatly increased
• blockade of cannabinoid receptors does not result in aggravation of kainic acid-induced seizures in mutants but does in wild-type controls
• treatment of mutants with endocannabinoid reuptake inhibitor causes a significant amelioration of kainic acid induced seizures
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• most seizures are myoclonic
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• some animals exhibit tonic-clonic seizures with age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen-treated mice exhibit decreased blood pressure following treatment with angiotensin II, vasopressin and endothelin compared to in wild-type mice
• tamoxifen-treated mice exposed to DOCA-salt do not develop hypertension and DOCA-salt treated mice exposed to tamoxifen following the onset of hypertension exhibit a drop in blood pressure compared to in similarly treated wild-type mice
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• following a normal transient increase in mean arterial blood pressure upon treatment with tamoxifen, mice exhibit a drop in mean arterial blood pressure below normal levels
• slight in the absence of tamoxifen induction
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• tamoxifen-treated mice fail to exhibit vasocontractile effects induced by phenylephrine or angiotensin II as do wild-type mice
• tamoxifen-treated mice exhibit reduced vasocontraction in response to serotonine, vasopressin, U46619 and endothelin-1 compared to similarly treated wild-type mice
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• tamoxifen-treated mice fail to exhibit vasocontractile effects induced by phenylephrine or angiotensin II as do wild-type mice
• tamoxifen-treated mice exhibit reduced vasocontraction in response to serotonine, vasopressin, U46619 and endothelin-1 compared to similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice with induction of cre recombinase, basal permeability is lower than controls
• vascular permeability does not increase above basal levels in response to histamine, IgE, platelet-activating factor (PAF), lysophosphatidic acid (LPA), or F2r-activating peptide
• mice are resistant to death resulting from PAF-induced shock
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| N |
• while resistant to shock induced by IgE or vasoactive substances, mice are not resistant to shock induced by LPS
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• tamoxifen treated mice are resistant to IgE-induced anaphylactic shock
• in an anti-DNP model, mice only have transient drops in systolic blood pressure compared to the sustained (>90 min) drops that occur in controls
• in an anti-BSA model, all mice survive anaphylactic challenge with only moderate decreases in body temperature compared to controls that suffer from severe hypothermia and death within 20 min of challenge
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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