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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dvl2tm1Awb
targeted mutation 1, Anthony Wynshaw-Boris
MGI:2429760
Summary 20 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dvl2tm1Awb/Dvl2tm1Awb either: 129S6/SvEvTac-Dvl2tm1Awb or (involves: 129S6/SvEvTac * NIH Swiss) MGI:2654555
hm2
Dvl2tm1Awb/Dvl2tm1Awb involves: 129S6/SvEvTac MGI:3831933
cx3
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss) MGI:2654558
cx4
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*K446M/EGFP)5Awb/?
involves: 129S6/SvEvTac MGI:3715993
cx5
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)4Awb/?
involves: 129S6/SvEvTac MGI:3715992
cx6
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)3Awb/?
involves: 129S6/SvEvTac MGI:3715991
cx7
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)1Awb/?
involves: 129S6/SvEvTac MGI:3715988
cx8
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)2Awb/?
involves: 129S6/SvEvTac MGI:3715989
cx9
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2+
involves: 129S6/SvEvTac MGI:3608684
cx10
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
involves: 129S6/SvEvTac MGI:3715978
cx11
Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+
involves: 129S6/SvEvTac * Black Swiss MGI:3831932
cx12
Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3+
involves: 129S6/SvEvTac * Black Swiss MGI:3831929
cx13
Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3tm1Awb
involves: 129S6/SvEvTac * Black Swiss MGI:3831930
cx14
Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3tm1Awb
involves: 129S6/SvEvTac * Black Swiss MGI:3831931
cx15
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
involves: 129S6/SvEvTac * C57BL/6 MGI:3715980
cx16
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
involves: 129S6/SvEvTac * LPT/LeJ MGI:3715981
cx17
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ MGI:3715984
cx18
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2Lp
involves: 129S6/SvEvTac * LPT/LeJ MGI:3715987
cx19
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ MGI:3608687
cx20
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)2Awb/?
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ MGI:3715990


Genotype
MGI:2654555
hm1
Allelic
Composition
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
either: 129S6/SvEvTac-Dvl2tm1Awb or (involves: 129S6/SvEvTac * NIH Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• incomplete penetrance; more than 50% die after E18.5

cardiovascular system
• exhibited by several embryos
• most common defect observed by mice with cardiovascular abnormalities
• frequently observed in conjuction with ventricular septal defects
• observed in a single embryo
• frequently observed in conjuction with double outlet right ventricle

embryo
• exhibited at E9.5 by 2-3% of mutant mice
• mild abnormalities in somite segmentation

homeostasis/metabolism
• surviving mice were predominantly female

limbs/digits/tail
• exhibited by 25% of surviving mice
• exhibited by some surviving mice

skeleton
• observed in one neonate
• affecting the sixth sternebra
• 90% displayed minor abnormalities
• normal rib number
• exhibited by surviving mutant mice
• 90% displayed minor abnormalities
• defects localized dorsally in vertebral ribs and vertebral bodies
• disorganized thoracic vertebrae

nervous system
• exhibited at E9.5 by 2-3% of mutant mice
• exhibited at E9.5 by 2-3% of mutant mice

hearing/vestibular/ear
N
• normal stereocilia orientation at E18.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dextro-looped transposition of the great arteries 1 DOID:0060771 OMIM:608808
J:96661




Genotype
MGI:3831933
hm2
Allelic
Composition
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die perinatally
• however, expression of a Dvl3 transgene can rescue perinatal lethality




Genotype
MGI:2654558
cx3
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• observed between E14.5 and E18.5
• observed between E14.5 and E18.5
• observed between E14.5 and E18.5

embryo
• completely open from midbrain to base of tail at E9.5-E10.5
• fusion observed at face and tail
• mild abnormalities in somite segmentation

skeleton
• extenisve fusion along the vertebral column
• defects more severe than those observed in Dvl2tm1Awb homozygous mutants
• collapsed vertebrae
• defects more severe than those observed in Dvl2tm1Awb homozygous mutants

nervous system
• completely open from midbrain to base of tail at E9.5-E10.5
• fusion observed at face and tail
• increased rows of hair cells within the third of the cochlea near the apex
• at E18.5 misoriented stereocilia bundles, more severe in the medial region than the base of the organ of Corti with approximately 35% misoriented in the two outer rows of outer hair cells, with denser cellular packing

hearing/vestibular/ear
• shorter, wider cochlear ducts
• increased rows of hair cells within the third of the cochlea near the apex
• at E18.5 misoriented stereocilia bundles, more severe in the medial region than the base of the organ of Corti with approximately 35% misoriented in the two outer rows of outer hair cells, with denser cellular packing




Genotype
MGI:3715993
cx4
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Tg(Dvl2*K446M/EGFP)5Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• seen in all mice at E9.5
• at P0, the stereociliary bundle orientation in the cochlea is disrupted and a less recognizable form of stereocilia is observed

hearing/vestibular/ear
• cochlea are wider and shorter
• at P0, the stereociliary bundle orientation in the cochlea is disrupted and a less recognizable form of stereocilia is observed

embryo
• seen in all mice at E9.5




Genotype
MGI:3715992
cx5
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)4Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Tg(Dvl2*/EGFP)4Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

embryo




Genotype
MGI:3715991
cx6
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)3Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Tg(Dvl2*/EGFP)3Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• neural tube closure defect is rescued




Genotype
MGI:3715988
cx7
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)1Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Tg(Dvl2/EGFP)1Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are restored to fertile adults




Genotype
MGI:3715989
cx8
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)2Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Tg(Dvl2/EGFP)2Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are restored to fertile adults




Genotype
MGI:3608684
cx9
Allelic
Composition
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• normal stereocilia orientation at E18.5




Genotype
MGI:3715978
cx10
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the floor plate is expanded
• neural tube fails to close in 100% of embryos
• the stereociliary bundle orientation in the cochlea is disrupted at 100% penetrance
• occasionally misaligned inner hair cells are obverse

hearing/vestibular/ear
• the stereociliary bundle orientation in the cochlea is disrupted at 100% penetrance
• occasionally misaligned inner hair cells are obverse

embryo
• at the 5- through 8- somite stage, the embryo length to width ratio is reduced
• there is no increase in embryo length to width ratio from 5 to 7 somite stage
• the floor plate is expanded
• neural tube fails to close in 100% of embryos
• the notochord is wider




Genotype
MGI:3831932
cx11
Allelic
Composition
Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E18.5, 11 of 28 mice exhibit conotruncal defects
• in 1 of 11 mice
• in 9 of 11 mice

hearing/vestibular/ear

nervous system




Genotype
MGI:3831929
cx12
Allelic
Composition
Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3+
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

embryo

nervous system

homeostasis/metabolism




Genotype
MGI:3831930
cx13
Allelic
Composition
Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3tm1Awb
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die prior to E8.5




Genotype
MGI:3831931
cx14
Allelic
Composition
Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3tm1Awb
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at P0

craniofacial

embryo
• at E18.5, mice exhibit shortening along the anterior-posterior axis
• in two mice

growth/size/body
• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail

hearing/vestibular/ear
• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice
• defects are more severe in mice also displaying craniorachischisis

limbs/digits/tail
• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail

nervous system
• in two mice
• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice
• defects are more severe in mice also displaying craniorachischisis




Genotype
MGI:3715980
cx15
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: 13% survive to adulthood on a mixed background

hearing/vestibular/ear
N
• stereociliary bundle orientation is normal in surviving mice

nervous system
• neural tube fails to close in less than 100% of embryos

embryo
• neural tube fails to close in less than 100% of embryos




Genotype
MGI:3715981
cx16
Allelic
Composition
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• similar to in Dvl2tm1Awb homozygotes only 50% of expected pups are recovered




Genotype
MGI:3715984
cx17
Allelic
Composition
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are recovered at birth

nervous system
• similar to that observed in Dvl1tm1Awb Dvl2tm1Awb Vangl2Lp triple homozygotes

embryo
• similar to that observed in Dvl1tm1Awb Dvl2tm1Awb Vangl2Lp triple homozygotes




Genotype
MGI:3715987
cx18
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2Lp
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (27 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

embryo




Genotype
MGI:3608687
cx19
Allelic
Composition
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• severe reduction in the embryo length to width ratio is observed similar to in Dvl1tm1Awb Dvl2tm1Awb Vangl2Lp triple homozygotes
• similar to that observed in Dvl1tm1Awb Dvl2tm1Awb Vangl2Lp triple homozygotes

hearing/vestibular/ear
• shorter, wider chochlear ducts
• increased rows of hair cells within the third of the cochlea nearest the apex
• misorientation of stereociliary bundles at E18.5
• occasionally misaligned inner hair cells are obverse

nervous system
• similar to that observed in Dvl1tm1Awb Dvl2tm1Awb Vangl2Lp triple homozygotes
• increased rows of hair cells within the third of the cochlea nearest the apex
• misorientation of stereociliary bundles at E18.5
• occasionally misaligned inner hair cells are obverse

mortality/aging
• no mice are recovered at birth




Genotype
MGI:3715990
cx20
Allelic
Composition
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)2Awb/?
Vangl2Lp/Vangl2+
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (24 available)
Tg(Dvl2/EGFP)2Awb mutation (0 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are restored to fertile adults





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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory