Mouse Genome Informatics
cx1
    Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(Alb-E2F1)8Sst/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• mutants develop diffuse liver dysplasia by 3 months of age
• 22% of mutants develop hepatocellular carcinomas by 6 months of age and by 9 months of age, 100% of mutants show hepatocellular carcinomas, indicating that tumors are more severe and arise faster than in single transgenic mice
• tumors are predominantly moderately well differentiated with trabecular, solid and trabecular/pseudoglandular pattern

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:101128 , J:170790


Mouse Genome Informatics
tg2
    Tg(Alb-E2F1)8Sst/0
involves: C57BL/6J * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• liver tumor progression begins with preneoplastic foci adjacent to portal tracts and pericentral large cell dysplasia at 2 months of age, followed by an abrupt increase in the number of neoplastic nodules or adenomas from 4-6 months onward, with 100% incidence by 10 months of age, and finally some adenomas show evidence of malignant transformation into trabecular hepatocellular carcinoma (J:65354)
• 100% incidence of adenomas by 10-12 months of age
• mice show features of malignant transformation in some of the adenomas by 10 months of age (J:65354)
• 60% of mutants develop hepatocellular carcinoma by 12 months of age (J:101128)
• tumors are predominantly well-differentiated (J:101128)

liver/biliary system
• livers show an increase in cell proliferation; at one month of age, the proliferation index is increased about 1.4-fold compared to wild-type, then proliferation decreases at 2 months of age so it is 2-fold lower than at 1 months of age but it is 6-fold higher than in wild-type livers at this time
• macrovesicular hepatic steatosis is first seen in livers at 6-8 months of age and by 10-12 months of age, 60% of mutants develop prominent fatty change

cellular
• livers show an increase in cell proliferation; at one month of age, the proliferation index is increased about 1.4-fold compared to wild-type, then proliferation decreases at 2 months of age so it is 2-fold lower than at 1 months of age but it is 6-fold higher than in wild-type livers at this time

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:65354 , J:101128 , J:170790