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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Vav-BCL2)1Jad
transgene insertion 1, Jerry M Adams
MGI:2429387
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Ighg1tm1(cre)Cgn/Ighg1+
Tg(Vav-BCL2)1Jad/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J MGI:5780071
cn2
Kmt2dtm1.1Kaig/Kmt2d+
Ighg1tm1(cre)Cgn/Ighg1+
Tg(Vav-BCL2)1Jad/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J MGI:5780072
cn3
Cd19tm1(cre)Cgn/Cd19+
Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Vav-BCL2)1Jad/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL MGI:3804187
cx4
Atp11cambr/Y
Tg(Vav-BCL2)1Jad/0
involves: C57BL/6 * C57BL/6J * C57BL/6JApb MGI:5006963
cx5
Sppl2am1Anu/Sppl2am1Anu
Tg(Vav-BCL2)1Jad/?
involves: C57BL/6JAnu MGI:5494311
tg6
Tg(Vav-BCL2)1Jad/0 involves: C57BL/6J MGI:3842939


Genotype
MGI:5780071
cn1
Allelic
Composition
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Ighg1tm1(cre)Cgn/Ighg1+
Tg(Vav-BCL2)1Jad/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (2 available); any Ighg1 mutation (10 available)
Kmt2dtm1.1Kaig mutation (1 available); any Kmt2d mutation (110 available)
Tg(Vav-BCL2)1Jad mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm
• diffuse large B cell lymphoma more so than in Tg(Vav-BCL2)1Jad mice
• more so than in Tg(Vav-BCL2)1Jad mice




Genotype
MGI:5780072
cn2
Allelic
Composition
Kmt2dtm1.1Kaig/Kmt2d+
Ighg1tm1(cre)Cgn/Ighg1+
Tg(Vav-BCL2)1Jad/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (2 available); any Ighg1 mutation (10 available)
Kmt2dtm1.1Kaig mutation (1 available); any Kmt2d mutation (110 available)
Tg(Vav-BCL2)1Jad mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm
• diffuse large B cell lymphoma as in Tg(Vav-BCL2)1Jad mice
• more so than in Tg(Vav-BCL2)1Jad mice




Genotype
MGI:3804187
cn3
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Tcf3tm1Mbu/Tcf3tm1.2Mbu
Tg(Vav-BCL2)1Jad/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Tcf3tm1.2Mbu mutation (0 available); any Tcf3 mutation (12 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (12 available)
Tg(Vav-BCL2)1Jad mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• GFP+ pre-B cells are absent in the bone marrow

immune system
• GFP+ pre-B cells are absent in the bone marrow




Genotype
MGI:5006963
cx4
Allelic
Composition
Atp11cambr/Y
Tg(Vav-BCL2)1Jad/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * C57BL/6JApb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation (2 available); any Atp11c mutation (5 available)
Tg(Vav-BCL2)1Jad mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes

hematopoietic system
• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes




Genotype
MGI:5494311
cx5
Allelic
Composition
Sppl2am1Anu/Sppl2am1Anu
Tg(Vav-BCL2)1Jad/?
Genetic
Background
involves: C57BL/6JAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl2am1Anu mutation (4 available); any Sppl2a mutation (7 available)
Tg(Vav-BCL2)1Jad mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in splenic B cells over non mutant controls but lower numbers than in animals carrying the transgene alone
• CD93- IgMlow mature B cells are increased 6.5X but CD93+ IgMhigh T1 B cell number is normal
• levels are about 12% of normal
• levels are about 12% of normal

hematopoietic system
• increase in splenic B cells over non mutant controls but lower numbers than in animals carrying the transgene alone
• CD93- IgMlow mature B cells are increased 6.5X but CD93+ IgMhigh T1 B cell number is normal
• levels are about 12% of normal
• levels are about 12% of normal




Genotype
MGI:3842939
tg6
Allelic
Composition
Tg(Vav-BCL2)1Jad/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 13 months of age

immune system
• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice
• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found
• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice
• 5-fold higher in the spleen at 18 weeks
• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice
• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice
• however, expansion of germinal centers is dependent on CD4 T cell help
• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice
• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis

neoplasm
• 12% of mice develop plasma cell tumors
• less than 10% of mice develop lymphoblastic lymphomas
• in less than 10% of mice
• less than 10% of mice develop large cell B lymphomas (J:88565)
• diffuse large B cell lymphoma (J:228913)
• at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma (J:88565)
• in less than 10% of mice

renal/urinary system
• mice develop hypercellular glomeruli that contain amorphous, eosinophilic deposits
• most capillaries are no longer patent
• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis
• Bowman epithelium proliferates to form crescents in the most advanced cases

endocrine/exocrine glands
• in less than 10% of mice

hematopoietic system
• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice
• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found
• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice
• 5-fold higher in the spleen at 18 weeks
• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice
• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice
• however, expansion of germinal centers is dependent on CD4 T cell help
• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice

cardiovascular system
• most capillaries are no longer patent

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
follicular lymphoma DOID:0050873 OMIM:151430
J:88565





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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory