All Phenotypes Map3k8<tm1Pnt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map3k8^tm1Pnt
targeted mutation 1, Phillip Tsichlis
MGI:2388714

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k8^tm1Pnt/Map3k8^tm1Pnt	involves: 129S1/Sv	MGI:3822911
hm2	Map3k8^tm1Pnt/Map3k8^tm1Pnt	involves: 129S1/Sv * C57BL/6J	MGI:2389024
cx3	Map3k8^tm1Pnt/Map3k8^tm1Pnt Tnf^tm2Gkl/Tnf⁺	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:3629606
cx4	Map3k8^tm1Pnt/Map3k8^tm1Pnt Nfkb1^tm1Sley/Nfkb1^tm1Sley	involves: 129S1/Sv * 129S4/SvJae	MGI:5491301

Allelic Composition	Map3k8^tm1Pnt/Map3k8^tm1Pnt
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:142340 , J:196528 )

• there is no difference from controls in the number or percentage of regulatory T cells, CD4⁺ and CD8⁺ memory T cells, and NKT cells found in the thymus and spleen (J:142340)

• the proliferative response of nave CD4⁺ T cells to TCR stimulation is also normal (J:142340)

• mice exhibit normal IL12b secretion and circulating levels (J:196528)

Allelic Composition	Map3k8^tm1Pnt/Map3k8^tm1Pnt
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:66503 )

• bone marrow, thymus, spleen and lymph nodes are hystologically normal and contain the all the expected cell subsets in normal ratios, mice show normal antibody responses to T-cell dependent antigen KLH and to T-cell independent antigens LPS-TNP, and T-cell mediated cytotoxic response against LCMV infected cells is normal

decreased tumor necrosis factor secretion ( J:66503 )

• in response to LPS mice secrete less TNF-alpha

• splenocytes, thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages are defective in TNF-alpha induction following LPS stimulation

decreased susceptibility to endotoxin shock ( J:66503 )

• mice were resistant to the induction of endotoxin shock

Allelic Composition	Map3k8^tm1Pnt/Map3k8^tm1Pnt Tnf^tm2Gkl/Tnf⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)
Tnf^tm2Gkl mutation (1 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small intestinal inflammation ( J:108572 )

• there is a delayed onset and significant attenuation of disease compared to controls

increased CD8-positive, alpha-beta T cell number ( J:108572 )

• number of CD8+CD44^hi T cells is higher than in Tnf^tm2Gkl/+ controls

increased single-positive T cell number ( J:108572 )

• there is a significant increase in numbers of CD4+ and CD8+ cells

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:108572 )

• number of CD8+CD44^hi T cells is higher than in Tnf^tm2Gkl/+ controls

increased single-positive T cell number ( J:108572 )

• there is a significant increase in numbers of CD4+ and CD8+ cells

digestive/alimentary system

small intestinal inflammation ( J:108572 )

• there is a delayed onset and significant attenuation of disease compared to controls

Allelic Composition	Map3k8^tm1Pnt/Map3k8^tm1Pnt Nfkb1^tm1Sley/Nfkb1^tm1Sley
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^tm1Pnt mutation (0 available); any Map3k8 mutation (41 available)
Nfkb1^tm1Sley mutation (0 available); any Nfkb1 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-12b level ( J:196528 )

• after LPS injection

decreased interleukin-12b secretion ( J:196528 )

• in bone marrow-derived macrophage

decreased tumor necrosis factor secretion ( J:196528 )

• from bone marrow-derived macrophage stimulated with LPS

• from primary peritoneal macrophages from mice stimulated with LPS

homeostasis/metabolism

decreased circulating interleukin-12b level ( J:196528 )

• after LPS injection

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