Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf3tm1Kge mutation
(0 available);
any
Ikzf3 mutation
(30 available)
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immune system
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• numbers of marginal zone B cells and presumed marginal zone B cell precursors are dramatically reduced
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• increase in IgDhi IgMlo mature follicular B cells
• increase in the ratio of IgDhi follicular B cells to IgMhiIgDloCD21lo newly formed B cells
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hematopoietic system
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• numbers of marginal zone B cells and presumed marginal zone B cell precursors are dramatically reduced
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• increase in IgDhi IgMlo mature follicular B cells
• increase in the ratio of IgDhi follicular B cells to IgMhiIgDloCD21lo newly formed B cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf3tm1Kge mutation
(0 available);
any
Ikzf3 mutation
(30 available)
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mortality/aging
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• incomplete penetrance, likely due to renal failure from SLE-like disease
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neoplasm
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• correlated with proliferative phenotype seen in B cells
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hematopoietic system
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• unimmunized mice at 2 months displayed numerous splenic germinal centers, suggestive of active, proliferative state
• increased B cell proliferation via the immunoglobulin receptor in vitro
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• increased T cell receptor mediated proliferation, but T cell development normal
• normal T cell-dependent immune responses, as assessed by antibody titers after immunization with TNP-OVA
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• evident between 3 and 6 months of age
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• concomitant 50% decrease in long-lived recirculating bone marrow B cells
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• 50% increase in the number of pre-B cells in the bone marrow compared to controls
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• small, 17% decrease in mature naive B cells
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• increased numbers of large, well developed germinal centers evident at 6 weeks of age
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• ill-defined marginal zone evident at 6 weeks of age
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homeostasis/metabolism
immune system
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• unimmunized mice at 2 months displayed numerous splenic germinal centers, suggestive of active, proliferative state
• increased B cell proliferation via the immunoglobulin receptor in vitro
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• increased T cell receptor mediated proliferation, but T cell development normal
• normal T cell-dependent immune responses, as assessed by antibody titers after immunization with TNP-OVA
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• evident between 3 and 6 months of age
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• concomitant 50% decrease in long-lived recirculating bone marrow B cells
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• 50% increase in the number of pre-B cells in the bone marrow compared to controls
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• small, 17% decrease in mature naive B cells
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• increased numbers of large, well developed germinal centers evident at 6 weeks of age
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• ill-defined marginal zone evident at 6 weeks of age
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• SLE-like phenotype seen
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• deposition of IgG, IgM, and C3 in glomeruli
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• autoantibodies reactive with kidney sections of wild-type mice were detected in 5 or 6 week old mutant mice, but not in controls
(J:50626)
• increased autoantibody (anti-ANA, anti-ssDNA, anti-dsDNA, anti-histone) concentrations in serum, especially in female mice
(J:81805)
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• hypercellularity, lobularity, segmental sclerosis, and enlarged glomeruli, caused by immune complex deposits
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renal/urinary system
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• incomplete penetrance, evident in several mice, indicative, along with increased creatinine and urea in serum, of renal failure
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• hypercellularity, lobularity, segmental sclerosis, and enlarged glomeruli, caused by immune complex deposits
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cellular
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• unimmunized mice at 2 months displayed numerous splenic germinal centers, suggestive of active, proliferative state
• increased B cell proliferation via the immunoglobulin receptor in vitro
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• increased T cell receptor mediated proliferation, but T cell development normal
• normal T cell-dependent immune responses, as assessed by antibody titers after immunization with TNP-OVA
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growth/size/body
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• evident between 3 and 6 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf3tm1Kge mutation
(0 available);
any
Ikzf3 mutation
(30 available)
Pou2af1tm1Pmt mutation
(0 available);
any
Pou2af1 mutation
(15 available)
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hematopoietic system
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• blocked transition from pre-B to immature B cells
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• failed to form germinal centers
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• of all types, relative to wild-type controls
• no development of autoantibodies as seen in Zfpn1a3tm1Kge mutant mice
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immune system
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• blocked transition from pre-B to immature B cells
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• failed to form germinal centers
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• of all types, relative to wild-type controls
• no development of autoantibodies as seen in Zfpn1a3tm1Kge mutant mice
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renal/urinary system
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• histological examination of kidneys showed no inflammation, no glomerular immune complex deposition
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkxid mutation
(3 available);
any
Btk mutation
(22 available)
Ikzf3tm1Kge mutation
(0 available);
any
Ikzf3 mutation
(30 available)
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hematopoietic system
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• decrease in IgDhi IgMlo mature follicular B cells, similar to that seen in single homozygous Btk mutant mice
• however, normal numbers of marginal zone B cells are observed
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immune system
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• decrease in IgDhi IgMlo mature follicular B cells, similar to that seen in single homozygous Btk mutant mice
• however, normal numbers of marginal zone B cells are observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkxid mutation
(3 available);
any
Btk mutation
(22 available)
Ikzf3tm1Kge mutation
(0 available);
any
Ikzf3 mutation
(30 available)
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hematopoietic system
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• decrease in IgDhi IgMlo mature follicular B cells, similar to that seen in single homozygous Btk mutant mice
• however, normal numbers of marginal zone B cells are observed
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immune system
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• decrease in IgDhi IgMlo mature follicular B cells, similar to that seen in single homozygous Btk mutant mice
• however, normal numbers of marginal zone B cells are observed
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Analysis Tools