Btk^xid
Spontaneous Allele Detail

Summary

• Symbol: Btk^xid
• Name: Bruton agammaglobulinemia tyrosine kinase; X linked immune deficiency
• MGI ID: MGI:1856317
• Synonyms: xid
• Gene: Btk Location: ChrX:133443085-133484319 bp, - strand Genetic Position: ChrX, 56.18 cM
• Alliance: Btk^xid page

Mutation origin

• Strain of Origin: CBA/HN

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The C to T substitution at coding nucleotide 82 changes codon 28 from an arginine to a cysteine (p.R28C). (J:13209)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Btk Mutation: 22 strains or lines available

References

• Original: J:6296 Berning AK, et al., Mapping of the X-linked immune deficiency mutation (xid) of CBA/N mice. J Immunol. 1980 Apr;124(4):1875-7
• All: 159 reference(s)