Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation
(3 available);
any
Atg7 mutation
(51 available)
Sqstm1tm1Keta mutation
(0 available);
any
Sqstm1 mutation
(32 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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nervous system
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• large pyramidal neurons in the hippocampus are absent
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• large pyramidal neurons in the cerebral cortex are absent
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• Purkinje cells in the cerebellum are absent in these mice
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• myelinated axons of the cerebellar nuclei are frequently enlarged and contain aberrant membranous structures and degenerated materials
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• the cytoplasmic inclusion bodies containing ubiquitinated proteins that are found in the brain of Atg7 conditional knockouts are largely absent in these mice
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• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex
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behavior/neurological
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• abnormal limb clasping is observed in mice
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cellular
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• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1antm1.1Rsjo mutation
(0 available);
any
Hif1an mutation
(15 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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homeostasis/metabolism
growth/size/body
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• at 8 week and 10 week time points mice fed 60% fat diet gain significantly less weight
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2Zqw mutation
(0 available);
any
Nbn mutation
(59 available)
Tg(Nes-cre)1Wme mutation
(1 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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nervous system
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N |
• brain weight and cerebellar morphology are normal unlike in mutants with wild-type Trp53
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behavior/neurological
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N |
• motor coordination defects seen in mutants with wild-type Trp53 are not seen in mutants that are homozygous null for Trp53
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neoplasm
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• similar to other Trp53 null mutations sarcomas and lymphomas are seen; however no cerebellar tumors have been detected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2Zqw mutation
(0 available);
any
Nbn mutation
(59 available)
Tg(Nes-cre)1Wme mutation
(1 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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nervous system
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• foliation structure is improved compared to mutants wild-type for Trp53
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• a marginal increase in granule cell numbers is seen compared to mutants wild-type for Trp53
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behavior/neurological
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• performance on the balance beam test is improved compared to mutants wild-type for Trp53 but is impaired compared to controls and mutants that are homozygous null for Trp53
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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mortality/aging
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• 2% of animals survive to weaning
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• animals born at less than the predicted Mendelian ratio
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growth/size/body
skeleton
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• fusion of neural arches
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vision/eye
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• severity of phenotype was variable
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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behavior/neurological
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N |
• capsaicin infusion into striatum does not affect exploratory or motor behavior in Cre-activated mutants or controls
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• infusion of capsaicin into striatum of results in stereotyped contralateral circling behavior within 5 minutes of delivery, while control mice without activation of Trpv1 show no effect
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nervous system
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• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures
• at doses sufficient to induce circling, no cell death is observed
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• in layer 5 cortical slices, capsaicin induces action potentials while cells from Cre-negative animals show no response
• neurons in slices show dose-dependent depolarizing currents in response to capsaicin applied to the bath
• capsaicin applied acutely to single cells causes reproducible bursts of action potentials with increases in firing rate; frequency of firing is dependent on duration and concentration of capsaicin application
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homeostasis/metabolism
cellular
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• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures
• at doses sufficient to induce circling, no cell death is observed
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cellular
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• cysts result from aberrant fate determination of stem cells to epidermal progenitors and their accelerated differentiation into epidermis
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integument
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• cysts in the dermal layer but not in the epidermis, close to hair follicles, frequently in the vibrissa region
• cysts are composed of epidermal cells aberrantly differentiated from mutant hair follicular stem cells
• cyst formation occurs after hair loss or after the first hair cycle
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• begin to lose hair 1-3 months after birth, when the first or second hair cycle terminates
• hair loss frequently occurs in the vibrissa region
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• hyperkeratinization of the epidermis on the back and tail
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• epidermis is thickened in some regions
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growth/size/body
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• cysts in the dermal layer but not in the epidermis, close to hair follicles, frequently in the vibrissa region
• cysts are composed of epidermal cells aberrantly differentiated from mutant hair follicular stem cells
• cyst formation occurs after hair loss or after the first hair cycle
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mortality/aging
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• mutant embryos die at E11.5
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embryo
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• the axial mesendoderm failed to differentiate; the anterior neural plate and anterior definitive endoderm form, but fail to maintain specification
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nervous system
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• anterior head truncations were noted in mutant animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2.1Zqw mutation
(0 available);
any
Nbn mutation
(59 available)
Nbntm2Zqw mutation
(0 available);
any
Nbn mutation
(59 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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nervous system
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• neural stem and progenitor cells from E13.5 brains produce fewer and smaller neurospheres in culture, do not produce secondary neurospheres, and have an increased number of chromosomal breaks per metaphase; however, no increase in apoptosis is seen
• no primary neurospheres were isolated from newborn mutants
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• at E15.5, E18.5, and P7, proliferation of cells is decreased in the outer external granule cell layer
• at E15.5, E18.5, and P7, apoptosis is increased in the inner external granule cell layer
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• at P0 the Purkinje cell layer is disorganized
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• at P0 the granule cell layer is disorganized with a reduction in the number of granule cells and ectopic presence of Purkinje cells
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• at P0 the Bergmann glia are abnormal
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behavior/neurological
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• when suspended by the tail mutants stretch out their hind limbs
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• cerebellar ataxia seen after P7
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• after P7 mutants are unable to complete the balance beam test
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• increased repetitive movements seen after P7
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growth/size/body
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• detected by P7 and mutants reach only about half of the body weight of control mice at weaning
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cellular
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• neural stem and progenitor cells from E13.5 brains produce fewer and smaller neurospheres in culture, do not produce secondary neurospheres, and have an increased number of chromosomal breaks per metaphase; however, no increase in apoptosis is seen
• no primary neurospheres were isolated from newborn mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2Zqw mutation
(0 available);
any
Nbn mutation
(59 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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nervous system
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• neural stem and progenitor cells from E13.5 brains produce fewer and smaller neurospheres in culture, do not produce secondary neurospheres, and have an increased number of chromosomal breaks per metaphase; however, no increase in apoptosis is seen
• no primary neurospheres were isolated from newborn mutants
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• at E15.5, E18.5, and P7, proliferation of cells is decreased in the outer external granule cell layer
• at E15.5, E18.5, and P7, apoptosis is increased in the inner external granule cell layer
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• at P0 the Purkinje cell layer is disorganized
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• at P0 the Bergmann glia are abnormal
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behavior/neurological
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• when suspended by the tail mutants stretch out their hind limbs
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• cerebellar ataxia seen after P7
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• after P7 mutants are unable to complete the balance beam test
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• increased repetitive movements seen after P7
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growth/size/body
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• detected by P7 and mutants reach only about half of the body weight of control mice at weaning
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cellular
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• no primary neurospheres were isolated from newborn mutants
• neural stem and progenitor cells from E13.5 brains produce fewer and smaller neurospheres in culture, do not produce secondary neurospheres, and have an increased number of chromosomal breaks per metaphase; however, no increase in apoptosis is seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10tm7Rsad mutation
(1 available);
any
Myh10 mutation
(95 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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mortality/aging
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• mice die between P12 and P22
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nervous system
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• paper-thin with the absence of most brain cortical tissue
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• at P7, the spinal canal is ablated unlike in wild-type mice
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behavior/neurological
cardiovascular system
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N |
• unlike null mice, cardiac development is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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hematopoietic system
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N |
• hematopoietic stem and progenitor cells of irradiated mice treated with tamoxifen do not exhibit a selective advantage over cells not expressing the modified cDNA
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• following irradiation, the proportion of GFP+ cells in the hematopoietic stem and progenitor cell compartment and myeloid and lymphoid lineages of tamoxifen-treated mice is increased compared to un-irradiated mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation
(3 available);
any
Atg7 mutation
(51 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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cellular
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• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins
• these inclusion bodies are visible two days after birth and grow in size and number during development
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• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex
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homeostasis/metabolism
nervous system
|
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• large pyramidal neurons in the hippocampus are absent
|
|
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• large pyramidal neurons in the cerebral cortex are absent
|
|
|
• myelinated axons of the cerebellar nuclei are frequently enlarged and contain aberrant membranous structures and degenerated material
|
|
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• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins
• these inclusion bodies are visible two days after birth and grow in size and number during development
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• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex
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behavior/neurological
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• abnormal limb clasping is observed in mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Wme mutation
(1 available)
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mortality/aging
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• all mice die within 5 weeks
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nervous system
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• in the developing cortex and cerebellum at E19.5 and P2
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• fewer reach the cortical plate
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• in all mice within the first month of age
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• secondary to the reduction in neural progenitors
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• at P2
• in all mice within the first month of age
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• at E19.5, the area occupied by the ventricle is 8-fold compared with wild-type mice
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• thin with disorganized layers at P8
• however, no defects are observed in the choroid plexus
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• loss and disorganization of myelinated axons at P18
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growth/size/body
behavior/neurological
cellular
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• in the brain of E12.5 embryo
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• in the developing cortex and cerebellum at E19.5 and P2
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• fewer reach the cortical plate
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Analysis Tools