Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsd11b1tm1Yko mutation
(0 available);
any
Hsd11b1 mutation
(27 available)
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homeostasis/metabolism
adipose tissue
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• less accumulation of visceral fat on a high fat diet
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• increased size of epididymal fat pad
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsd11b1tm1Yko mutation
(0 available);
any
Hsd11b1 mutation
(27 available)
|
|
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Hsd11b1tm1Yko/Hsd11b1tm1Ykomice show lipid accumulation in the liver
homeostasis/metabolism
endocrine/exocrine glands
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• adrenocortical hyperplasia
(J:37960)
• enlarged male adrenal glands
(J:45085)
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respiratory system
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• impaired fetal lung maturation
• reduced lung surfactant protein-A (SP-A) mRNA and protein levels
• reduced amniotic fluid lecithin/sphingomyelin ratios
• reduced number and density of surfactant complexes in the alveoli
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• normally developed alveoli but with type II pneumocytes interposed in alveolar septa
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• many alveoli lack lamellar bodies by E19
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• only a few lamellar bodies can be found in the alveolar lumen
• these are smaller and their density is low
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• reduced lung surfactant protein-A (SP-A) mRNA and protein levels
• reduced number and density of surfactant complexes in the alveoli
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behavior/neurological
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• improved performance of older mice in cued plateform watermaze test relative to aged controls
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nervous system
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• significantly less retention of corticosterone
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• significantly less retention of corticosterone
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adipose tissue
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• less accumulation of visceral fat on a high fat diet
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• increased size of epididymal fat pad
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liver/biliary system
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• liver glycogen levels are significantly elevated when fed
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• increased accumulation of lipid in the liver of fasted mutants; this lipid accumulation is resolved upon refeeding
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