Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1Tyb mutation
(0 available);
any
Syk mutation
(42 available)
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immune system
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• neutrophils exhibit impaired degranulation in response to bacteria compared with wild-type cells
• bacteria-stimulated neutrophils exhibit altered cytokine profiles and secret less TNF-alpha compared with similarly treated wild-type cells
• bacteria-bound neutrophils exhibit less superoxidation than similarly treated wild-type cells
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• neutrophils exhibit reduced S. aureus phagocytosis and modest reductions in E. coli phagocytosis compared with similarly treated wild-type cells
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• neutrophils exhibit reduced killing of S. aureus and modest reductions in the killing of E. coli compared with similarly treated wild-type cells
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• CD8alpha+ dendritic cells have a specific defect in efficient cross-presentation of dead-cell associated antigens
• CD8alpha+ dendritic cells are able to uptake necrotic cells, present soluble antigen, and present antigen conjugated to beads (a model of cross presentation)
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• bacteria-stimulated neutrophils secret less TNF-alpha compared with similarly treated wild-type cells
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hematopoietic system
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• neutrophils exhibit impaired degranulation in response to bacteria compared with wild-type cells
• bacteria-stimulated neutrophils exhibit altered cytokine profiles and secret less TNF-alpha compared with similarly treated wild-type cells
• bacteria-bound neutrophils exhibit less superoxidation than similarly treated wild-type cells
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• neutrophils exhibit reduced S. aureus phagocytosis and modest reductions in E. coli phagocytosis compared with similarly treated wild-type cells
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• neutrophils exhibit reduced killing of S. aureus and modest reductions in the killing of E. coli compared with similarly treated wild-type cells
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cellular
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• neutrophils exhibit reduced S. aureus phagocytosis and modest reductions in E. coli phagocytosis compared with similarly treated wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1Tyb mutation
(0 available);
any
Syk mutation
(42 available)
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skeleton
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• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation
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• osteoclast fail to resorb mineralized matrix in vivo unlike wild-type cells
• neither treatment of osteoclast precursors with large doses of macrophage colony stimulating factor nor coculture with wild-type osteoblasts can rescue bone resoprtion
• however, transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore bone resoption
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immune system
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• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation
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hematopoietic system
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• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation
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cellular
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• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells
• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation
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Allelic
Composition |
Syktm1Tyb/Syktm1Tyb
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Genetic
Background |
involves: 129S2/SvPas * C57BL/6 * DBA/2 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1Tyb mutation
(0 available);
any
Syk mutation
(42 available)
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mortality/aging
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• many homozygotes die shortly after birth
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• only 1 of 227 mice at 10-20 days of age was a homozygote
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cardiovascular system
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• at E16.5 extensive hemorrhaging is seen in all homozygotes but by E18.5 hemorrages are seen in only 45% of homozygotes
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immune system
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• at 2 days of age no IgM+ B cells are found in the spleen and cultured fetal liver cells fail to produce IgM+ B cells
• radiation chimeras reconstituted with homozygous fetal liver cells have virtually no mature B cells and reduced numbers of pre-B cells
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• at E16.5 and E18.5 the number of mature Vgamma3+ thymocytes is reduced or undetectable; however in radiation chimeras the numbers of CD4+ and CD8+ T cells is similar to wild-type
• T cell numbers in the skin are reduced to about 60% of wild-type
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homeostasis/metabolism
hematopoietic system
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• at 2 days of age no IgM+ B cells are found in the spleen and cultured fetal liver cells fail to produce IgM+ B cells
• radiation chimeras reconstituted with homozygous fetal liver cells have virtually no mature B cells and reduced numbers of pre-B cells
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• at E16.5 and E18.5 the number of mature Vgamma3+ thymocytes is reduced or undetectable; however in radiation chimeras the numbers of CD4+ and CD8+ T cells is similar to wild-type
• T cell numbers in the skin are reduced to about 60% of wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1Tyb mutation
(0 available);
any
Syk mutation
(42 available)
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immune system
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• at P0, lymphatic vessels in the lungs contain blood cells unlike in wild-type mice
• mice exhibit a connection between the vasculature and lymphatic systems
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• the ratio of lymphatic endothelial cells to blood endothelial cells is reduced in the lungs compared to in control mice
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cardiovascular system
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• mice exhibit a connection between the vasculature and lymphatic systems unlike in wild-type mice
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• in the brain (parenchyma) at E12.5 persisting through E18.5
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• at E12.5 persisting through E18.5
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respiratory system
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• larger airways contain fluid droplets unlike in control mice
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• some terminal air sacs fail to properly inflate
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nervous system
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• mice exhibit a connection between the vasculature and lymphatic systems unlike in wild-type mice
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• in the brain (parenchyma) at E12.5 persisting through E18.5
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• at E12.5 persisting through E18.5
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immune system
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• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice
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hematopoietic system
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• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.2Tara mutation
(1 available);
any
Syk mutation
(42 available)
Syktm1Tyb mutation
(0 available);
any
Syk mutation
(42 available)
Tg(S100A8-cre,-EGFP)1Ilw mutation
(1 available)
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immune system
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• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice
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hematopoietic system
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• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice
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immune system
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• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice
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• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice
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hematopoietic system
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• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice
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• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice
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Analysis Tools