Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcktm1Hev mutation
(0 available);
any
Hck mutation
(29 available)
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immune system
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• neutrophil degranulation following adhesion is decreased compared to in wild-type mice
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, 73% mice exhibit no hemorrhages or fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice wild-type mice
• however, neutrophil migration is normal
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hematopoietic system
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• neutrophil degranulation following adhesion is decreased compared to in wild-type mice
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Allelic
Composition |
Hcktm1Hev/Hcktm1Hev
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Genetic
Background |
involves: 129S7/SvEvBrd * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcktm1Hev mutation
(0 available);
any
Hck mutation
(29 available)
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immune system
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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hematopoietic system
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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cellular
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation
(0 available);
any
Fgr mutation
(129 available)
Hcktm1Hev mutation
(0 available);
any
Hck mutation
(29 available)
Lyntm1Sor mutation
(2 available);
any
Lyn mutation
(64 available)
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immune system
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit no hemorrhages and reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice
• however, neutrophil migration is normal
|
hematopoietic system
|
|
• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgrtm1Hev mutation
(0 available);
any
Fgr mutation
(129 available)
Hcktm1Hev mutation
(0 available);
any
Hck mutation
(29 available)
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immune system
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• reduced numbers of filopodia and increased lamellopodia related membrane structures
• abnormal F-actin organization
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• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits
• impaired migration
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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• impaired ability to resolve infection with Listeria monocytogenes
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cardiovascular system
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• angiogenic responses to Cxcl1 and Cxcl2 are disrupted
• neutrophile responses normal but they fail to release VEGF-A in response to Cxcl1 and Cxcl2
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hematopoietic system
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• reduced numbers of filopodia and increased lamellopodia related membrane structures
• abnormal F-actin organization
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• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits
• impaired migration
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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cellular
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• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcktm1Hev mutation
(0 available);
any
Hck mutation
(29 available)
Srctm1Sor mutation
(2 available);
any
Src mutation
(144 available)
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mortality/aging
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• approximately 50% die immediately after weaning
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• double homozygotes present at dramatically reduced proportions at 10-14 days of age
• ratios normal at E18.5
• deaths probably occurring perinatally
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growth/size/body
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• little weight gain from 14 to 50 days of age
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skeleton
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• proximal and distal growth zones are often fused leaving the diaphysis filled with cancellous bone
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• reduced bone marrow cavity
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• extensive development of cancellous bone reduces bone marrow cavity in long bones, vertebral bodies, sternum
• accumulations of poorly remodeled osteocartilagenous trabeculae throughout the growth zones of long bones
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• proximal and distal growth zones are often fused leaving the diaphysis filled with cancellous bone
• normal numbers of osteoclasts found
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immune system
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• accumulation of mature macrophage in bones
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• mild leucopenia at 2-4 weeks of age which is more severe at E18.5
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• reduced cell number in thymus
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• absent or poorly formed germinal centers
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• increased number of colony forming units in spleen
• greatly increased numbers of immature myeloid cells
• decreased numbers of lymphoid cells
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• reduced number of cells in lymph nodes but structure otherwise normal
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hematopoietic system
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• reduced cell number in thymus
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• mild anemia at 2-4 weeks of age which is more severe at E18.5
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• reduced number of colony forming units in bone marrow
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• accumulation of mature macrophage in bones
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• mild leucopenia at 2-4 weeks of age which is more severe at E18.5
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• absent or poorly formed germinal centers
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• increased number of colony forming units in spleen
• greatly increased numbers of immature myeloid cells
• decreased numbers of lymphoid cells
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endocrine/exocrine glands
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• reduced cell number in thymus
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Analysis Tools